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Tbio
AIFM2
Apoptosis-inducing factor 2

Protein Summary
Description
Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307864
  • ENSP00000312370
  • ENSG00000042286
  • ENST00000373248
  • ENSP00000362345
  • ENST00000613322
  • ENSP00000478931

Symbol
  • AMID
  • PRG3
  • AMID
  • PRG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.74
histone modification site profile
0.73
cellular component
0.68
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.04   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.04   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
38.8
eyelid sagging measurement
1
1
0
4
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
38.8
eyelid sagging measurement
0
4
33.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
apoptosis inducing factor, mitochondria associated 2
711037
Mouse
MGI:1918611
71361
Rat
RGD:1304964
361843
Dog
apoptosis inducing factor, mitochondria associated 2
VGNC:37738
479236
Horse
apoptosis inducing factor, mitochondria associated 2
VGNC:15187
100063387
Species
Name
OMA
EggNOG
Inparanoid
Macaque
apoptosis inducing factor, mitochondria associated 2
Mouse
Rat
Dog
apoptosis inducing factor, mitochondria associated 2
Horse
apoptosis inducing factor, mitochondria associated 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRQ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (81)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Protein-Protein Interactions (39)
1 – 10 of 39
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.998518753
p_ni:  0.001481247
Data Source:  BioPlex
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.998185225
p_ni:  0.001814775
Data Source:  BioPlex
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.994579186
p_ni:  0.005420814
Data Source:  BioPlex
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.976988537
p_ni:  0.023004382
p_wrong:  0.000007081
Data Source:  BioPlex
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.962711788
p_ni:  0.037288212
Data Source:  BioPlex
ECHDC1
Tbio
Family:  Enzyme
Novelty:  0.02711265
p_int:  0.959290695
p_ni:  0.040709305
Data Source:  BioPlex
SESTD1
Tbio
Novelty:  0.2052002
p_int:  0.94804698
p_ni:  0.04409813
p_wrong:  0.00785489
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.902698174
p_ni:  0.097301826
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.931
Data Source:  STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
Score:  0.8
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.04

PubMed score by year
PubTator Score  13.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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