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Tbio
CHCHD6
MICOS complex subunit MIC25

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290913
  • ENSP00000290913
  • ENSG00000159685

Symbol
  • CHCM1
  • MIC25
  • CHCM1
  • Mic25
  • MICOS25
  • PPP1R23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.64
cell type or tissue
0.62
transcription factor perturbation
0.61
interacting protein
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 6
VGNC:7965
460663
Macaque
coiled-coil-helix-coiled-coil-helix domain containing 6
716767
Mouse
MGI:1913348
66098
Rat
RGD:1304561
297436
Cow
coiled-coil-helix-coiled-coil-helix domain containing 6
VGNC:27274
615934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 6
Macaque
coiled-coil-helix-coiled-coil-helix domain containing 6
Mouse
Rat
Cow
coiled-coil-helix-coiled-coil-helix domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRQ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.994674345
p_ni: 0.005325642
p_wrong: 1.3e-8
Data Source: BioPlex
MTX2
Tbio
Novelty: 0.02047483
p_int: 0.987848031
p_ni: 0.012151969
Score: 0.997
Data Source: BioPlex,STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
p_int: 0.963406525
p_ni: 0.036593475
Score: 0.261
Data Source: BioPlex,STRINGDB
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.886699493
p_ni: 0.113300505
p_wrong: 2e-9
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.877227916
p_ni: 0.122770064
p_wrong: 0.000002021
Score: 0.265
Data Source: BioPlex,STRINGDB
SLC22A16
Tbio
Family: Transporter
Novelty: 0.03379851
p_int: 0.789826456
p_ni: 0.210173544
Score: 0.158
Data Source: BioPlex,STRINGDB
CD244
Tbio
Novelty: 0.01137579
p_int: 0.783578165
p_ni: 0.216421834
p_wrong: 2e-9
Score: 0.704
Data Source: BioPlex,STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.997
Data Source: STRINGDB
IMMT
Tbio
Novelty: 0.00260309
Score: 0.993
Data Source: STRINGDB
CHCHD2
Tbio
Novelty: 0.01615338
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.52

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer