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Tbio
OVOL2
Transcription factor Ovo-like 2

Protein Summary
Description
Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes tha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278780
  • ENSP00000278780
  • ENSG00000125850

Symbol
  • ZNF339
  • CHED
  • CHED1
  • CHED2
  • PPCD1
  • ZNF339
  • EUROIMAGE566589
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
phenotype
0.83
PubMedID
0.77
gene perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.19   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.19   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
62.1
red blood cell density measurement
1
1
1
54.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
62.1
red blood cell density measurement
1
54.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ovo like zinc finger 2
VGNC:9938
737338
Mouse
MGI:1338039
107586
Rat
RGD:1306130
296201
Dog
ovo like zinc finger 2
VGNC:44197
485753
Horse
ovo like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ovo like zinc finger 2
Mouse
Rat
Dog
ovo like zinc finger 2
Horse
ovo like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
GRHL2
Tbio
Family: TF
Novelty: 0.01092611
Score: 0.719
Data Source: STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
Score: 0.693
Data Source: STRINGDB
SNX5
Tbio
Novelty: 0.04075649
Score: 0.628
Data Source: STRINGDB
ESRP1
Tbio
Novelty: 0.02035464
Score: 0.622
Data Source: STRINGDB
PRR15
Tbio
Novelty: 0.19831311
Score: 0.613
Data Source: STRINGDB
CCDC88A
Tbio
Novelty: 0.01077253
Score: 0.594
Data Source: STRINGDB
RBBP5
Tbio
Novelty: 0.02221059
Score: 0.569
Data Source: STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
Score: 0.56
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.516
Data Source: STRINGDB
DZANK1
Tdark
Novelty: 1.1964364
Score: 0.512
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.19

PubMed score by year
PubTator Score  16.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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