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Tbio
TM2D3
TM2 domain-containing protein 3

Protein Summary
Description
The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333202
  • ENSP00000330433
  • ENSG00000184277
  • ENST00000347970
  • ENSP00000327584

Symbol
  • BLP2
  • BLP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
histone modification site profile
0.74
transcription factor binding site profile
0.69
gene perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
3
3
73.2
apolipoprotein A 1 measurement
1
1
1
13.1
red blood cell density measurement
1
1
1
9.4
high density lipoprotein cholesterol measurement
1
1
1
3.3
apolipoprotein B measurement
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
73.2
apolipoprotein A 1 measurement
1
13.1
red blood cell density measurement
1
9.4
high density lipoprotein cholesterol measurement
1
3.3
apolipoprotein B measurement
1
1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 3
VGNC:1594
738514
Macaque
TM2 domain containing 3
695111
Mouse
MGI:1915884
68634
Dog
TM2 domain containing 3
VGNC:47406
479020
Horse
TM2 domain containing 3
VGNC:24139
100057905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 3
Macaque
TM2 domain containing 3
Mouse
Dog
TM2 domain containing 3
Horse
TM2 domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRN9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (53)
1 – 10 of 53
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.999878735
p_ni:  0.000121262
p_wrong:  3e-9
Score:  0.372
Data Source:  BioPlex,STRINGDB
TM2D1
Tdark
Novelty:  0.1760181
p_int:  0.999598453
p_ni:  0.000401546
p_wrong:  1e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
SPCS2
Tdark
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.962585399
p_ni:  0.037414601
Score:  0.54
Data Source:  BioPlex,STRINGDB
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.955685738
p_ni:  0.044314262
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.952106416
p_ni:  0.047887721
p_wrong:  0.000005863
Data Source:  BioPlex
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.928812561
p_ni:  0.071187392
p_wrong:  4.7e-8
Data Source:  BioPlex
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
p_int:  0.921553968
p_ni:  0.065803967
p_wrong:  0.012642065
Score:  0.644
Data Source:  BioPlex,STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.913320067
p_ni:  0.085583935
p_wrong:  0.001095998
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.908484776
p_ni:  0.090722692
p_wrong:  0.000792531
Data Source:  BioPlex
DDX39A
Tbio
Family:  Enzyme
Novelty:  0.0373703
p_int:  0.907051517
p_ni:  0.092948483
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.90

PubMed score by year
PubTator Score  6.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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