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Tdark
SEC22C
Vesicle-trafficking protein SEC22c

Protein Summary
Description
May be involved in vesicle transport between the ER and the Golgi complex. This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264454
  • ENSP00000264454
  • ENSG00000093183
  • ENST00000273156
  • ENSP00000273156
  • ENST00000417572
  • ENSP00000407564
  • ENST00000423701
  • ENSP00000414576

Symbol
  • SEC22L3
  • SEC22L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
1
1
70.2
body fat distribution
1
1
1
17.8
body height
1
1
1
6.3
CCL2 measurement
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
70.2
body fat distribution
1
17.8
body height
1
6.3
CCL2 measurement
1
5.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC22 homolog C, vesicle trafficking protein
VGNC:12185
460292
Macaque
SEC22 homolog C, vesicle trafficking protein
716351
Mouse
MGI:2447871
215474
Rat
RGD:1590146
687022
Dog
SEC22 homolog C, vesicle trafficking protein
VGNC:45968
485615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC22 homolog C, vesicle trafficking protein
Macaque
SEC22 homolog C, vesicle trafficking protein
Mouse
Rat
Dog
SEC22 homolog C, vesicle trafficking protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRL7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (139)
1 – 10 of 139
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
p_int:  0.999450006
p_ni:  0.000549994
Score:  0.542
Data Source:  BioPlex,STRINGDB
IL1RN
Tchem
Novelty:  0.00070533
p_int:  0.995880121
p_ni:  0.004119868
p_wrong:  1.1e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
p_int:  0.993387637
p_ni:  0.006612363
Score:  0.455
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.91160218
p_ni:  0.08839782
Score:  0.203
Data Source:  BioPlex,STRINGDB
POLG2
Tbio
Family:  Enzyme
Novelty:  0.0233323
p_int:  0.910497764
p_ni:  0.089502233
p_wrong:  3e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
p_int:  0.784095876
p_ni:  0.215904124
Score:  0.465
Data Source:  BioPlex,STRINGDB
GOSR2
Tbio
Novelty:  0.02447711
Score:  0.996
Data Source:  STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.991
Data Source:  STRINGDB
BET1
Tdark
Novelty:  0.01791164
Score:  0.989
Data Source:  STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.981
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.43

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer