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Tbio
SRSF8
Serine/arginine-rich splicing factor 8

Protein Summary
Description
Involved in pre-mRNA alternative splicing. This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587424
  • ENSP00000480140
  • ENSG00000263465

Symbol
  • SFRS2B
  • SRP46
  • DSM-1
  • SRP46
  • SFRS2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
tissue sample
0.75
transcription factor perturbation
0.68
cell line
0.67
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.999779191
p_ni:  0.000220807
p_wrong:  2e-9
Score:  0.498
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.999449635
p_ni:  0.000550304
p_wrong:  6.1e-8
Score:  0.742
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999295411
p_ni:  0.000685558
p_wrong:  0.000019031
Data Source:  BioPlex
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.999170947
p_ni:  0.000393721
p_wrong:  0.000435333
Score:  0.457
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.999054845
p_ni:  0.000580053
p_wrong:  0.000365102
Data Source:  BioPlex
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.998605403
p_ni:  0.001391694
p_wrong:  0.000002904
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.997797164
p_ni:  0.002201506
p_wrong:  0.00000133
Score:  0.462
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.997720637
p_ni:  0.002274829
p_wrong:  0.000004533
Score:  0.517
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.997712244
p_ni:  0.002279243
p_wrong:  0.000008513
Score:  0.752
Data Source:  BioPlex,STRINGDB
SREK1
Tbio
Novelty:  0.19228162
p_int:  0.996939242
p_ni:  0.0030594
p_wrong:  0.000001358
Score:  0.777
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
96.1
reticulocyte measurement
2
2
2
72.8
reticulocyte count
2
1
2
59
platelet count
1
1
1
48.5
mean reticulocyte volume
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
96.1
reticulocyte measurement
2
72.8
reticulocyte count
2
59
platelet count
1
48.5
mean reticulocyte volume
1
41.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 5.25
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title