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Tbio
LZTS2
Leucine zipper putative tumor suppressor 2

Protein Summary
Description
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decreas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370220
  • ENSP00000359240
  • ENSG00000107816
  • ENST00000370223
  • ENSP00000359243

Symbol
  • KIAA1813
  • LAPSER1
  • LAPSER1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
0.89
transcription factor binding site profile
0.85
transcription factor
0.81
viral protein
0.8
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
84.6
serum gamma-glutamyl transferase measurement
1
2
2
58.3
mitochondrial heteroplasmy measurement
1
1
1
53.7
refractive error measurement
2
1
1
5.5
40.7
puberty onset measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
84.6
serum gamma-glutamyl transferase measurement
2
58.3
mitochondrial heteroplasmy measurement
1
53.7
refractive error measurement
1
5.5
40.7
puberty onset measurement
1
33.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
leucine zipper tumor suppressor 2
711279
Mouse
MGI:2385095
226154
Rat
RGD:1359249
365468
Dog
leucine zipper tumor suppressor 2
VGNC:52997
486846
Horse
leucine zipper tumor suppressor 2
VGNC:19874
100060415
Species
Name
OMA
EggNOG
Inparanoid
Macaque
leucine zipper tumor suppressor 2
Mouse
Rat
Dog
leucine zipper tumor suppressor 2
Horse
leucine zipper tumor suppressor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (94)
1 – 10 of 94
LZTS1
Tbio
Novelty:  0.02747372
p_int:  0.999999851
p_ni:  1.49e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.99999964
p_ni:  3.6e-7
Data Source:  BioPlex
SESTD1
Tbio
Novelty:  0.2052002
p_int:  0.999998232
p_ni:  0.000001768
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999997536
p_ni:  0.00000246
p_wrong:  3e-9
Data Source:  BioPlex
DYRK1B
Tchem
Family:  Kinase
Novelty:  0.01960932
p_int:  0.99999611
p_ni:  0.000003601
p_wrong:  2.89e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
ZNF74
Tbio
Family:  TF
Novelty:  0.10554307
p_int:  0.999994669
p_ni:  0.000005325
p_wrong:  6e-9
Data Source:  BioPlex
SSX2IP
Tbio
Novelty:  0.01381625
p_int:  0.99998539
p_ni:  0.000013998
p_wrong:  6.12e-7
Data Source:  BioPlex
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.999981139
p_ni:  0.000018297
p_wrong:  5.64e-7
Score:  0.499
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999976006
p_ni:  0.000023986
p_wrong:  8e-9
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999970345
p_ni:  0.000029487
p_wrong:  1.67e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  13.85

PubMed score by year
PubTator Score  7.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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