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Tbio
MESP1
Mesoderm posterior protein 1

Protein Summary
Description
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300057
  • ENSP00000300057
  • ENSG00000166823

Symbol
  • BHLHC5
  • bHLHc5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.84
virus perturbation
0.83
transcription factor binding site profile
0.69
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mesoderm posterior bHLH transcription factor 1
VGNC:1919
104002423
Macaque
mesoderm posterior bHLH transcription factor 1
700744
Mouse
MGI:107785
17292
Rat
RGD:1311751
308766
Dog
mesoderm posterior bHLH transcription factor 1
VGNC:43163
100856667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mesoderm posterior bHLH transcription factor 1
Macaque
mesoderm posterior bHLH transcription factor 1
Mouse
Rat
Dog
mesoderm posterior bHLH transcription factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRJ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Cardiac Progenitor Differentiation
WikiPathways
Cardiac Progenitor Differentiation
WikiPathways
Cardiac Progenitor Differentiation
WikiPathways
Cardiac Progenitor Differentiation
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
Name
Explore in Pharos
Explore in Source
Cardiac Progenitor Differentiation
Cardiac Progenitor Differentiation
Cardiac Progenitor Differentiation
Cardiac Progenitor Differentiation
Pathways Affected in Adenoid Cystic Carcinoma
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (41)
1 – 10 of 41
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.72
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.677
Data Source: STRINGDB
TBX5
Tbio
Family: TF
Novelty: 0.00272208
Score: 0.675
Data Source: STRINGDB
FOXC2
Tbio
Family: TF
Novelty: 0.00438844
Score: 0.655
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.654
Data Source: STRINGDB
SOX17
Tbio
Family: TF
Novelty: 0.00328146
Score: 0.646
Data Source: STRINGDB
EOMES
Tbio
Family: TF
Novelty: 0.00288125
Score: 0.646
Data Source: STRINGDB
FOXC1
Tbio
Family: TF
Novelty: 0.00387011
Score: 0.644
Data Source: STRINGDB
LFNG
Tbio
Family: Enzyme
Novelty: 0.02660238
Score: 0.627
Data Source: STRINGDB
ZFPM2
Tbio
Family: TF
Novelty: 0.01019523
Score: 0.599
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.01

PubMed score by year
PubTator Score  31.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer