Tbio SLC30A2 Zinc transporter 2

Protein Classes

PANTHER Classes

Protein / Transporter / Zinc Transporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc30 Zinc Transporter Family / Zinc Transporter 2

Protein Summary

Description

The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q9BRI3
• Q71RC8
• ZnT-2

Gene Name

• SLC30A2

Ensembl ID

• ENST00000374276
• ENSP00000363394
• ENSG00000158014
• ENST00000374278
• ENSP00000363396

Symbol

• ZNT2
• TNZD
• ZNT2
• ZnT-2
• PP12488

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
PubMedID	0.66
cellular component	0.63
tissue	0.49
transcription factor	0.48

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.24   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.24   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 30 member 2	VGNC:8109	469239
Macaque	solute carrier family 30 member 2		713732
Mouse	solute carrier family 30 (zinc transporter), member 2	MGI:106637	230810
Rat	solute carrier family 30 member 2	RGD:3707	25362
Dog	solute carrier family 30 member 2	VGNC:46347	478173

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 30 member 2
Macaque	solute carrier family 30 member 2
Mouse	solute carrier family 30 (zinc transporter), member 2
Rat	solute carrier family 30 member 2
Dog	solute carrier family 30 member 2

Pathways (9)

Reactome (6)

WikiPathways (3)

Metal ion SLC transporters (R-HSA-425410)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metal ion SLC transporters	26 targets	R-HSA-425410
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551
Reactome	Zinc efflux and compartmentalization by the SLC30 family	7 targets	R-HSA-435368

Name	Explore in Pharos	Explore in Source
Metal ion SLC transporters	26 targets	R-HSA-425410
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551
Zinc efflux and compartmentalization by the SLC30 family	7 targets	R-HSA-435368

Gene Ontology Terms (11)

Functions (1)

Components (6)

Processes (4)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (52)

Explore Interacting Targets

1 – 10 of 52

• See Interactions on String-DB

SLC39A4

Tbio

Family: Transporter

Novelty: 0.00742159

Score: 0.847

Data Source: STRINGDB

SLC30A9

Tbio

Family: Transporter

Novelty: 0.07156604

Score: 0.822

Data Source: STRINGDB

SLC39A5

Tbio

Family: Transporter

Novelty: 0.05205571

Score: 0.802

Data Source: STRINGDB

SLC39A7

Tbio

Family: Transporter

Novelty: 0.01746862

Score: 0.783

Data Source: STRINGDB

SLC39A9

Tbio

Family: Transporter

Novelty: 0.06143625

Score: 0.763

Data Source: STRINGDB

SLC39A10

Tbio

Family: Transporter

Novelty: 0.03527885

Score: 0.756

Data Source: STRINGDB

SLC39A13

Tbio

Family: Transporter

Novelty: 0.03474449

Score: 0.754

Data Source: STRINGDB

SLC39A14

Tbio

Family: Transporter

Novelty: 0.01053215

Score: 0.748

Data Source: STRINGDB

SLC39A6

Tbio

Family: Transporter

Novelty: 0.0144314

Score: 0.745

Data Source: STRINGDB

SLC39A11

Tbio

Family: Transporter

Novelty: 0.09770302

Score: 0.743

Data Source: STRINGDB

Publication Statistics

PubMed Score  58.24

PubMed score by year

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PubTator Score  29.61

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Complete proteome
Disease mutation
Ion transport
Lysosome
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport

MGI Phenotype Find Similar Targets

cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype