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Tbio
SLC30A2
Zinc transporter 2

Protein Summary
Description
The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374276
  • ENSP00000363394
  • ENSG00000158014
  • ENST00000374278
  • ENSP00000363396

Symbol
  • ZNT2
  • TNZD
  • ZNT2
  • ZnT-2
  • PP12488
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
PubMedID
0.66
cellular component
0.63
tissue
0.49
transcription factor
0.48


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.42   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.42   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
9
62.1
IGF-1 measurement
1
1
1
27.2
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
9
62.1
IGF-1 measurement
1
27.2
1
8.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 2
VGNC:8109
469239
Macaque
solute carrier family 30 member 2
713732
Mouse
MGI:106637
230810
Rat
RGD:3707
25362
Dog
solute carrier family 30 member 2
VGNC:46347
478173
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 2
Macaque
solute carrier family 30 member 2
Mouse
Rat
Dog
solute carrier family 30 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRI3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc efflux and compartmentalization by the SLC30 family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc efflux and compartmentalization by the SLC30 family
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (52)
1 – 10 of 52
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
Score:  0.847
Data Source:  STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
Score:  0.822
Data Source:  STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
Score:  0.802
Data Source:  STRINGDB
SLC39A7
Tbio
Family:  Transporter
Novelty:  0.01746862
Score:  0.783
Data Source:  STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
Score:  0.763
Data Source:  STRINGDB
SLC39A10
Tbio
Family:  Transporter
Novelty:  0.03527885
Score:  0.756
Data Source:  STRINGDB
SLC39A13
Tbio
Family:  Transporter
Novelty:  0.03474449
Score:  0.754
Data Source:  STRINGDB
SLC39A14
Tbio
Family:  Transporter
Novelty:  0.01053215
Score:  0.748
Data Source:  STRINGDB
SLC39A6
Tbio
Family:  Transporter
Novelty:  0.0144314
Score:  0.745
Data Source:  STRINGDB
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
Score:  0.743
Data Source:  STRINGDB
Publication Statistics
PubMed Score  58.42

PubMed score by year
PubTator Score  29.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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