SLC30A2
Zinc transporter 2
Protein Classes
Protein Summary
The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000374276
- ENSP00000363394
- ENSG00000158014
- ENST00000374278
- ENSP00000363396
- ZNT2
- TNZD
- ZNT2
- ZnT-2
- PP12488
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.93 | ||
PubMedID | 0.66 | ||
cellular component | 0.63 | ||
tissue | 0.49 | ||
transcription factor | 0.48 | ||
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.42 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 41 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.42 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 41 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 1 | 9 | 62.1 | |||||
IGF-1 measurement | 1 | 1 | 1 | 27.2 | |||||
1 | 1 | 1 | 8.9 | ||||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 9 | 62.1 | |||||
IGF-1 measurement | 1 | 27.2 | |||||
1 | 8.9 | ||||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 30 member 2 | VGNC:8109 | 469239 | |||||
Macaque | solute carrier family 30 member 2 | 713732 | ||||||
Mouse | MGI:106637 | 230810 | ||||||
Rat | RGD:3707 | 25362 | ||||||
Dog | solute carrier family 30 member 2 | VGNC:46347 | 478173 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 30 member 2 | |||||
Macaque | solute carrier family 30 member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 30 member 2 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (9)
Reactome (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metal ion SLC transporters | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Reactome | Transport of small molecules | ||||
Reactome | Zinc efflux and compartmentalization by the SLC30 family | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metal ion SLC transporters | ||||
SLC-mediated transmembrane transport | ||||
Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Transport of small molecules | ||||
Zinc efflux and compartmentalization by the SLC30 family | ||||
Gene Ontology Terms (11)
Functions (1)
Components (6)
Processes (4)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (52)
1 – 10 of 52
SLC39A4
Family: Transporter
Novelty: 0.00742159
Score: 0.847
Data Source: STRINGDB
SLC30A9
Family: Transporter
Novelty: 0.07156604
Score: 0.822
Data Source: STRINGDB
SLC39A5
Family: Transporter
Novelty: 0.05205571
Score: 0.802
Data Source: STRINGDB
SLC39A7
Family: Transporter
Novelty: 0.01746862
Score: 0.783
Data Source: STRINGDB
SLC39A9
Family: Transporter
Novelty: 0.06143625
Score: 0.763
Data Source: STRINGDB
SLC39A10
Family: Transporter
Novelty: 0.03527885
Score: 0.756
Data Source: STRINGDB
SLC39A13
Family: Transporter
Novelty: 0.03474449
Score: 0.754
Data Source: STRINGDB
SLC39A14
Family: Transporter
Novelty: 0.01053215
Score: 0.748
Data Source: STRINGDB
SLC39A6
Family: Transporter
Novelty: 0.0144314
Score: 0.745
Data Source: STRINGDB
SLC39A11
Family: Transporter
Novelty: 0.09770302
Score: 0.743
Data Source: STRINGDB
Publication Statistics
PubMed Score 58.42
PubMed score by year
PubTator Score 29.61
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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