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Tbio
VPS25
Vacuolar protein-sorting-associated protein 25

Protein Summary
Description
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253794
  • ENSP00000253794
  • ENSG00000131475

Symbol
  • DERP9
  • EAP20
  • DERP9
  • EAP20
  • FAP20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor binding site profile
0.89
interacting protein
0.86
cellular component
0.79
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Endosomal Sorting Complex Required For Transport (ESCRT) (R-HSA-917729)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Endosomal Sorting Complex Required For Transport (ESCRT)
Membrane Trafficking
Vesicle-mediated transport
Protein-Protein Interactions (82)
1 – 10 of 82
VPS36
Tbio
Novelty: 0.04226354
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SNF8
Tbio
Novelty: 0.0473195
p_int: 0.999999977
p_ni: 1.4e-8
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RABGGTA
Tbio
Family: Enzyme
Novelty: 0.18518519
p_int: 0.998304497
p_ni: 0.001695503
Data Source: BioPlex
NAPG
Tbio
Novelty: 0.02021534
p_int: 0.987273483
p_ni: 0.012722534
p_wrong: 0.000003983
Data Source: BioPlex
BAP1
Tbio
Family: Enzyme
Novelty: 0.00594927
p_int: 0.970725916
p_ni: 0.026846378
p_wrong: 0.002427706
Data Source: BioPlex
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.13346044
p_int: 0.848793884
p_ni: 0.151206116
Data Source: BioPlex
DAXX
Tbio
Novelty: 0.00430069
p_int: 0.846033264
p_ni: 0.153959123
p_wrong: 0.000007613
Data Source: BioPlex
KIFAP3
Tbio
Novelty: 0.03856985
p_int: 0.819839547
p_ni: 0.1240903
p_wrong: 0.056070153
Score: 0.195
Data Source: BioPlex,STRINGDB
CHMP6
Tbio
Novelty: 0.0478065
Score: 0.999
Data Source: STRINGDB
VPS28
Tbio
Novelty: 0.04542177
Score: 0.997
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  19.31

PubMed score by year
PubTator Score  7.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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