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Tbio
CPPED1
Serine/threonine-protein phosphatase CPPED1

Protein Summary
Description
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261660
  • ENSP00000261660
  • ENSG00000103381
  • ENST00000381774
  • ENSP00000371193
  • ENST00000433677
  • ENSP00000411127

Symbol
  • CSTP1
  • CSTP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.78
histone modification site profile
0.74
cell type or tissue
0.7
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (128)
1 – 10 of 128
SEPSECS
Tbio
Family: Enzyme
Novelty: 0.00791538
p_int: 0.836514112
p_ni: 1.39e-7
p_wrong: 0.163485748
Score: 0.687
Data Source: BioPlex,STRINGDB
MNDA
Tbio
Novelty: 0.02515459
Score: 0.928
Data Source: STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00182748
Score: 0.925
Data Source: STRINGDB
CTSA
Tchem
Family: Enzyme
Novelty: 0.00073662
Score: 0.917
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00045103
Score: 0.916
Data Source: STRINGDB
GUSB
Tchem
Family: Enzyme
Novelty: 0.00074055
Score: 0.914
Data Source: STRINGDB
PYCARD
Tbio
Novelty: 0.00561282
Score: 0.913
Data Source: STRINGDB
LYZ
Tbio
Family: Enzyme
Novelty: 0.00100348
Score: 0.913
Data Source: STRINGDB
CTSC
Tchem
Family: Enzyme
Novelty: 0.00041764
Score: 0.912
Data Source: STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.0023816
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.26

PubMed score by year
PubTator Score  3.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer