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Tbio
PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Protein Summary
Description
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000026218
  • ENSP00000026218
  • ENSG00000007541
  • ENST00000321878
  • ENSP00000326674
  • ENST00000409527
  • ENSP00000386760
  • ENST00000470411
  • ENSP00000439650

Symbol
  • GPI1
  • GPI1
  • c407A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
small molecule perturbation
0.94
kinase perturbation
0.84
disease perturbation
0.74
metabolite
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (75)
1 – 10 of 75
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.999880169
p_ni:  0.00011983
p_wrong:  2e-9
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.999869136
p_ni:  0.000130765
p_wrong:  9.9e-8
Data Source:  BioPlex
JTB
Tbio
Novelty:  0.06646216
p_int:  0.999768747
p_ni:  0.000224843
p_wrong:  0.00000641
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.998488878
p_ni:  0.001492177
p_wrong:  0.000018945
Score:  0.197
Data Source:  BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.997989938
p_ni:  0.002004447
p_wrong:  0.000005615
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.993526603
p_ni:  0.006406948
p_wrong:  0.000066449
Score:  0.157
Data Source:  BioPlex,STRINGDB
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.993526603
p_ni:  0.006406948
p_wrong:  0.000066449
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.985086603
p_ni:  0.012714383
p_wrong:  0.002199014
Score:  0.209
Data Source:  BioPlex,STRINGDB
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.973135953
p_ni:  0.023252816
p_wrong:  0.00361123
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.972791606
p_ni:  0.024790025
p_wrong:  0.002418369
Data Source:  BioPlex
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
90.6
reticulocyte measurement
2
2
2
85.8
mean corpuscular volume
1
1
1
84
mean reticulocyte volume
1
2
2
81.8
reticulocyte count
2
1
2
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
90.6
reticulocyte measurement
2
85.8
mean corpuscular volume
1
84
mean reticulocyte volume
2
81.8
reticulocyte count
2
76.1
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class Q
VGNC:13777
467856
Macaque
phosphatidylinositol glycan anchor biosynthesis class Q
696123
Mouse
MGI:1333114
14755
Rat
RGD:1359535
287159
Dog
phosphatidylinositol glycan anchor biosynthesis class Q
VGNC:44539
490095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class Q
Macaque
phosphatidylinositol glycan anchor biosynthesis class Q
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class Q
Publication Statistics
PubMed Score 37.47
PubMed score by year
PubTator Score 15.02
PubTator score by year