Tbio TXNDC17 Thioredoxin domain-containing protein 17

Protein Summary

Description

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

Uniprot Accession IDs

• Q9BRA2
• A8K7E8

Gene Name

• TXNDC17

Ensembl ID

• ENST00000250101
• ENSP00000250101
• ENSG00000129235

Symbol

• TXNL5
• TRP14
• TXNL5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
small molecule perturbation	0.87
histone modification site profile	0.83
transcription factor binding site profile	0.76
cell type or tissue	0.69

Protein Classes

PANTHER Classes

Protein / Transporter / Thioredoxin Domain-containing Protein 17

DTO Classes

Protein / Transporter / Thioredoxin Domain-containing Protein 17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.92   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.92   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0