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Tbio
ACBD6
Acyl-CoA-binding domain-containing protein 6

Protein Summary
Description
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367595
  • ENSP00000356567
  • ENSG00000230124
  • ENST00000642319
  • ENSP00000495710
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
trait
0.93
transcription factor perturbation
0.88
kinase perturbation
0.76
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
Score:  0.881
Data Source:  STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
Score:  0.845
Data Source:  STRINGDB
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
Score:  0.727
Data Source:  STRINGDB
TMEM53
Tdark
Novelty:  0.75877723
Score:  0.725
Data Source:  STRINGDB
CACNA1E
Tchem
Family:  IC
Novelty:  0.00314898
Score:  0.676
Data Source:  STRINGDB
NDUFB10
Tclin
Family:  Enzyme
Novelty:  0.05791757
Score:  0.65
Data Source:  STRINGDB
ACBD3
Tbio
Novelty:  0.02992688
Score:  0.646
Data Source:  STRINGDB
ZNF23
Tbio
Family:  TF
Novelty:  0.33673708
Score:  0.605
Data Source:  STRINGDB
TMEM270
Tdark
Novelty:  1.34034992
Score:  0.588
Data Source:  STRINGDB
NTPCR
Tbio
Family:  Enzyme
Novelty:  0.0638186
Score:  0.586
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
29
chronotype measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
29
chronotype measurement
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 6
VGNC:52913
469602
Macaque
acyl-CoA binding domain containing 6
716418
Mouse
MGI:1919732
72482
Rat
RGD:1305030
289125
Dog
acyl-CoA binding domain containing 6
VGNC:49787
480029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 6
Macaque
acyl-CoA binding domain containing 6
Mouse
Rat
Dog
acyl-CoA binding domain containing 6
Publication Statistics
PubMed Score 4.44
PubMed score by year
PubTator Score 3.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title