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Tbio
RTP3
Receptor-transporting protein 3

Protein Summary
Description
Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296142
  • ENSP00000296142
  • ENSG00000163825

Symbol
  • TMEM7
  • Z3CXXC3
  • LTM1
  • TMEM7
  • Z3CXXC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.52
tissue
0.45
protein domain
0.41
transcription factor
0.41
tissue sample
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
2
0
1.1
93.2
macrophage inflammatory protein 1b measurement
1
2
2
90.9
CCL2 measurement
2
2
2
87.4
monocyte percentage of leukocytes
1
2
2
87.2
monocyte count
1
1
1
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
93.2
macrophage inflammatory protein 1b measurement
2
90.9
CCL2 measurement
2
87.4
monocyte percentage of leukocytes
2
87.2
monocyte count
1
73.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor transporter protein 3
VGNC:10340
470811
Dog
receptor transporter protein 3
VGNC:45799
609398
Horse
receptor transporter protein 3 [Source:HGNC Symbol;Acc:HGNC:15572]
Cow
receptor transporter protein 3
VGNC:54478
618086
Xenopus
receptor (chemosensory) transporter protein 3
XB-GENE-940866
100127813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor transporter protein 3
Dog
receptor transporter protein 3
Horse
receptor transporter protein 3 [Source:HGNC Symbol;Acc:HGNC:15572]
Cow
receptor transporter protein 3
Xenopus
receptor (chemosensory) transporter protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQQ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (413)
1 – 10 of 413
GNAL
Tbio
Novelty:  0.01757098
Score:  0.925
Data Source:  STRINGDB
OR5B21
Tdark
Family:  oGPCR
Score:  0.919
Data Source:  STRINGDB
OR51E1
Tbio
Family:  oGPCR
Novelty:  0.05230721
Score:  0.916
Data Source:  STRINGDB
OR6P1
Tdark
Family:  oGPCR
Novelty:  11.7597471
Score:  0.913
Data Source:  STRINGDB
OR6A2
Tdark
Family:  oGPCR
Novelty:  0.08554292
Score:  0.91
Data Source:  STRINGDB
OR6B1
Tdark
Family:  oGPCR
Novelty:  1.63220691
Score:  0.91
Data Source:  STRINGDB
OR1L8
Tdark
Family:  oGPCR
Novelty:  12.32613054
Score:  0.907
Data Source:  STRINGDB
OR10J5
Tdark
Family:  oGPCR
Novelty:  0.42152783
Score:  0.906
Data Source:  STRINGDB
OR51E2
Tchem
Family:  oGPCR
Novelty:  0.02435259
Score:  0.906
Data Source:  STRINGDB
OR2T27
Tdark
Family:  oGPCR
Novelty:  1.76296296
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.62

PubMed score by year
PubTator Score  5.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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