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Tdark
PSD2
PH and SEC7 domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274710
  • ENSP00000274710
  • ENSG00000146005

Symbol
  • EFA6C
  • EFA6C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
protein domain
0.73
cell line
0.61
tissue sample
0.6
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.999428878
p_ni:  0.000571103
p_wrong:  1.9e-8
Data Source:  BioPlex
FARP1
Tbio
Novelty:  0.04040696
p_int:  0.998712592
p_ni:  0.001287376
p_wrong:  3.2e-8
Data Source:  BioPlex
ZBTB49
Tdark
Family:  TF
Novelty:  2.32287223
p_int:  0.994795348
p_ni:  0.005202627
p_wrong:  0.000002024
Data Source:  BioPlex
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.994756415
p_ni:  0.005243564
p_wrong:  2.1e-8
Data Source:  BioPlex
DCAF16
Tdark
Novelty:  0.35666992
p_int:  0.993938825
p_ni:  0.004889921
p_wrong:  0.001171254
Data Source:  BioPlex
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.989289131
p_ni:  0.010709885
p_wrong:  9.85e-7
Data Source:  BioPlex
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.986835179
p_ni:  0.013164795
p_wrong:  2.6e-8
Data Source:  BioPlex
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.892342779
p_ni:  0.107657221
Data Source:  BioPlex
PPM1G
Tbio
Family:  Enzyme
Novelty:  0.02646519
p_int:  0.796547016
p_ni:  0.203452984
Data Source:  BioPlex
TRMT11
Tbio
Family:  Enzyme
Novelty:  0.11506701
p_int:  0.792556554
p_ni:  0.207290305
p_wrong:  0.000153141
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
56
BMI-adjusted hip circumference
2
3
3
50.5
body mass index
2
1
2
17.3
platelet count
1
1
1
11.1
platelet crit
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
56
BMI-adjusted hip circumference
3
50.5
body mass index
2
17.3
platelet count
1
11.1
platelet crit
1
11.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing 2
VGNC:4137
462110
Macaque
pleckstrin and Sec7 domain containing 2
694873
Mouse
MGI:1921252
74002
Rat
RGD:1311075
307500
Dog
pleckstrin and Sec7 domain containing 2
VGNC:45083
487157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing 2
Macaque
pleckstrin and Sec7 domain containing 2
Mouse
Rat
Dog
pleckstrin and Sec7 domain containing 2
Publication Statistics
PubMed Score 31.68
PubMed score by year
PubTator Score 9.64
PubTator score by year
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Related Publications
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PMID
Year
Title