Tdark PSD2 PH and SEC7 domain-containing protein 2

Protein Summary

Uniprot Accession IDs

• Q9BQI7
• D3DQD3
• Q8N3J8

Gene Name

• PSD2

Ensembl ID

• ENST00000274710
• ENSP00000274710
• ENSG00000146005

Symbol

• EFA6C
• EFA6C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
protein domain	0.73
cell line	0.61
tissue sample	0.6
cell type or tissue	0.57

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 17   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pleckstrin and Sec7 domain containing 2	VGNC:4137	462110
Macaque	pleckstrin and Sec7 domain containing 2		694873
Mouse	pleckstrin and Sec7 domain containing 2	MGI:1921252	74002
Rat	pleckstrin and Sec7 domain containing 2	RGD:1311075	307500
Dog	pleckstrin and Sec7 domain containing 2	VGNC:45083	487157

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pleckstrin and Sec7 domain containing 2
Macaque	pleckstrin and Sec7 domain containing 2
Mouse	pleckstrin and Sec7 domain containing 2
Rat	pleckstrin and Sec7 domain containing 2
Dog	pleckstrin and Sec7 domain containing 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9BQI7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Gene Ontology Terms (10)

Functions (2)

Components (7)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Electronic Annotation (IEA)	InterPro
phospholipid binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

FARP2

Tbio

Novelty: 0.09590913

p_int: 0.999428878

p_ni: 0.000571103

p_wrong: 1.9e-8

Data Source: BioPlex

FARP1

Tbio

Novelty: 0.04040696

p_int: 0.998712592

p_ni: 0.001287376

p_wrong: 3.2e-8

Data Source: BioPlex

ZBTB49

Tdark

Family: TF

Novelty: 2.32287223

p_int: 0.994795348

p_ni: 0.005202627

p_wrong: 0.000002024

Data Source: BioPlex

UHRF1

Tbio

Family: Epigenetic

Novelty: 0.00482565

p_int: 0.994756415

p_ni: 0.005243564

p_wrong: 2.1e-8

Data Source: BioPlex

DCAF16

Tdark

Novelty: 0.35666992

p_int: 0.993938825

p_ni: 0.004889921

p_wrong: 0.001171254

Data Source: BioPlex

NMT2

Tchem

Family: Enzyme

Novelty: 0.04826835

p_int: 0.989289131

p_ni: 0.010709885

p_wrong: 9.85e-7

Data Source: BioPlex

SETD2

Tchem

Family: Epigenetic

Novelty: 0.00178899

p_int: 0.986835179

p_ni: 0.013164795

p_wrong: 2.6e-8

Data Source: BioPlex

NMT1

Tchem

Family: Enzyme

Novelty: 0.00343834

p_int: 0.892342779

p_ni: 0.107657221

Data Source: BioPlex

PPM1G

Tbio

Family: Enzyme

Novelty: 0.02646519

p_int: 0.796547016

p_ni: 0.203452984

Data Source: BioPlex

TRMT11

Tbio

Family: Enzyme

Novelty: 0.11506701

p_int: 0.792556554

p_ni: 0.207290305

p_wrong: 0.000153141

Data Source: BioPlex

Publication Statistics

PubMed Score  30.65

PubMed score by year

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PubTator Score  9.64

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Cell projection
Coiled coil
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

MGI Phenotype Find Similar Targets

hearing/vestibular/ear phenotype
hematopoietic system phenotype
immune system phenotype