Tdark PSD2 PH and SEC7 domain-containing protein 2

Protein Summary

Uniprot Accession IDs

• Q9BQI7
• D3DQD3
• Q8N3J8

Gene Name

• PSD2

Ensembl ID

• ENST00000274710
• ENSP00000274710
• ENSG00000146005

Symbol

• EFA6C
• EFA6C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
protein domain	0.73
cell line	0.61
tissue sample	0.6
cell type or tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 17   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

FARP2

Tbio

Novelty:  0.09590913

p_int:  0.999428878

p_ni:  0.000571103

p_wrong:  1.9e-8

Data Source:  BioPlex

FARP1

Tbio

Novelty:  0.04040696

p_int:  0.998712592

p_ni:  0.001287376

p_wrong:  3.2e-8

Data Source:  BioPlex

ZBTB49

Tdark

Family:  TF

Novelty:  2.32287223

p_int:  0.994795348

p_ni:  0.005202627

p_wrong:  0.000002024

Data Source:  BioPlex

UHRF1

Tbio

Family:  Epigenetic

Novelty:  0.00482565

p_int:  0.994756415

p_ni:  0.005243564

p_wrong:  2.1e-8

Data Source:  BioPlex

DCAF16

Tdark

Novelty:  0.35666992

p_int:  0.993938825

p_ni:  0.004889921

p_wrong:  0.001171254

Data Source:  BioPlex

NMT2

Tchem

Family:  Enzyme

Novelty:  0.04826835

p_int:  0.989289131

p_ni:  0.010709885

p_wrong:  9.85e-7

Data Source:  BioPlex

SETD2

Tchem

Family:  Epigenetic

Novelty:  0.00178899

p_int:  0.986835179

p_ni:  0.013164795

p_wrong:  2.6e-8

Data Source:  BioPlex

NMT1

Tchem

Family:  Enzyme

Novelty:  0.00343834

p_int:  0.892342779

p_ni:  0.107657221

Data Source:  BioPlex

PPM1G

Tbio

Family:  Enzyme

Novelty:  0.02646519

p_int:  0.796547016

p_ni:  0.203452984

Data Source:  BioPlex

TRMT11

Tbio

Family:  Enzyme

Novelty:  0.11506701

p_int:  0.792556554

p_ni:  0.207290305

p_wrong:  0.000153141

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (7)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Electronic Annotation (IEA)	InterPro
phospholipid binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2	2	2		56
BMI-adjusted hip circumference	EFO_0008039	2	3	3		50.5
body mass index	EFO_0004340	2	1	2		17.3
platelet count	EFO_0004309	1	1	1		11.1
platelet crit	EFO_0007985	1	1	1		11.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2		56
BMI-adjusted hip circumference	EFO_0008039	3		50.5
body mass index	EFO_0004340	2		17.3
platelet count	EFO_0004309	1		11.1
platelet crit	EFO_0007985	1		11.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Cell projection
Coiled coil
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
body mass index
platelet count
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
hearing/vestibular/ear phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pleckstrin and Sec7 domain containing 2	VGNC:4137	462110
Macaque	pleckstrin and Sec7 domain containing 2		694873
Mouse	pleckstrin and Sec7 domain containing 2	MGI:1921252	74002
Rat	pleckstrin and Sec7 domain containing 2	RGD:1311075	307500
Dog	pleckstrin and Sec7 domain containing 2	VGNC:45083	487157

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pleckstrin and Sec7 domain containing 2
Macaque	pleckstrin and Sec7 domain containing 2
Mouse	pleckstrin and Sec7 domain containing 2
Rat	pleckstrin and Sec7 domain containing 2
Dog	pleckstrin and Sec7 domain containing 2

Publication Statistics

PubMed Score 31.68

PubMed score by year

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PubTator Score 9.64

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title