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Tbio
SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

Protein Summary
Description
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237247
  • ENSP00000237247
  • ENSG00000118473
  • ENST00000371037
  • ENSP00000360076
  • ENST00000371039
  • ENSP00000360078
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
microRNA
0.66
phenotype
0.61
trait
0.61
transcription factor
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
3
96.5
unipolar depression
2
3
2
1
84.9
lifestyle measurement
2
1
2
77.2
2
1
2
68.2
pulse pressure measurement
1
1
1
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
96.5
unipolar depression
2
1
84.9
lifestyle measurement
2
77.2
2
68.2
pulse pressure measurement
1
49.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain GRB2 like endophilin interacting protein 1
VGNC:10998
456924
Macaque
SH3 domain GRB2 like endophilin interacting protein 1
699558
Mouse
MGI:1920344
73094
Rat
RGD:1564957
313413
Dog
SH3 domain GRB2 like endophilin interacting protein 1
VGNC:46096
100856415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain GRB2 like endophilin interacting protein 1
Macaque
SH3 domain GRB2 like endophilin interacting protein 1
Mouse
Rat
Dog
SH3 domain GRB2 like endophilin interacting protein 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BQI5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (192)
1 – 10 of 192
SH3GL3
Tbio
Novelty: 0.05467913
Score: 0.992
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.984
Data Source: STRINGDB
AP2A1
Tbio
Novelty: 0.08554974
Score: 0.978
Data Source: STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
Score: 0.974
Data Source: STRINGDB
REPS1
Tbio
Novelty: 0.08952347
Score: 0.97
Data Source: STRINGDB
SH3GL2
Tbio
Novelty: 0.0188955
Score: 0.966
Data Source: STRINGDB
ITSN1
Tbio
Novelty: 0.01327346
Score: 0.965
Data Source: STRINGDB
AMPH
Tbio
Novelty: 0.00201043
Score: 0.964
Data Source: STRINGDB
SNAP91
Tbio
Novelty: 0.0083886
Score: 0.951
Data Source: STRINGDB
STON2
Tbio
Novelty: 0.02098671
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.85

PubMed score by year
PubTator Score  5.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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