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Tbio
NUDT12
Peroxisomal NADH pyrophosphatase NUDT12

Protein Summary
Description
Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230792
  • ENSP00000230792
  • ENSG00000112874
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.85
virus perturbation
0.68
tissue sample
0.56
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
KERA
Tbio
Novelty:  0.00789599
p_int:  0.999999988
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.76
Data Source:  BioPlex,STRINGDB
BLMH
Tbio
Family:  Enzyme
Novelty:  0.00855614
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.869
Data Source:  BioPlex,STRINGDB
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999999904
p_ni:  9.1e-8
p_wrong:  6e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
p_int:  0.999999413
p_ni:  5.84e-7
p_wrong:  4e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
ZNF517
Tdark
Family:  TF
Novelty:  1.60617003
p_int:  0.999993989
p_ni:  0.000005972
p_wrong:  3.9e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
NCOA5
Tbio
Novelty:  0.09053523
p_int:  0.999989816
p_ni:  0.000010184
Score:  0.219
Data Source:  BioPlex,STRINGDB
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.999972195
p_ni:  0.000027805
Score:  0.721
Data Source:  BioPlex,STRINGDB
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.999955746
p_ni:  0.000044236
p_wrong:  1.8e-8
Data Source:  BioPlex
PDLIM1
Tbio
Novelty:  0.02703639
p_int:  0.999930627
p_ni:  0.000069369
p_wrong:  4e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.999924089
p_ni:  0.000075911
Score:  0.269
Data Source:  BioPlex,STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 12
VGNC:4109
461977
Macaque
nudix hydrolase 12
703898
Mouse
MGI:1915243
67993
Rat
RGD:1310902
367323
Dog
nudix hydrolase 12
VGNC:44025
488881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 12
Macaque
nudix hydrolase 12
Mouse
Rat
Dog
nudix hydrolase 12
Publication Statistics
PubMed Score 5.60
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title