Tbio MYBBP1A Myb-binding protein 1A

Protein Summary

Description

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q9BQG0
• Q86VM3
• Q9BW49
• Q9P0V5
• Q9UF99

Gene Name

• MYBBP1A

Ensembl ID

• ENST00000254718
• ENSP00000254718
• ENSG00000132382
• ENST00000381556
• ENSP00000370968

Symbol

• P160
• P160
• PAP2
• Pol5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
kinase perturbation	0.91
hub protein	0.9
histone modification site profile	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Myb-binding Protein 1a

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Myb-binding Protein 1a

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Myb-binding Protein 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.03   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.03   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0