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Tbio
MYBBP1A
Myb-binding protein 1A

Protein Summary
Description
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254718
  • ENSP00000254718
  • ENSG00000132382
  • ENST00000381556
  • ENSP00000370968

Symbol
  • P160
  • P160
  • PAP2
  • Pol5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
kinase perturbation
0.91
hub protein
0.9
histone modification site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.03   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.03   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (271)
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.973825957
p_ni:  0.026174043
Score:  0.946
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.951491643
p_ni:  0.048508357
Score:  0.484
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.929739274
p_ni:  0.070260726
Score:  0.17
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.895673645
p_ni:  0.104326355
Score:  0.529
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.895345149
p_ni:  0.104654851
Data Source:  BioPlex
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.887932906
p_ni:  0.112067094
Score:  0.656
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.887448828
p_ni:  0.112551172
Score:  0.314
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.884976692
p_ni:  0.115023308
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.873553695
p_ni:  0.126446305
Score:  0.293
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.865831127
p_ni:  0.134168873
Score:  0.618
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (217)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

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Find Similar Targets
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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Positive epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Positive epigenetic regulation of rRNA expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
7
10
91.7
eosinophil percentage of leukocytes
2
5
6
90.7
1
1
0
3.1
87.9
sum of eosinophil and basophil counts
1
3
3
84.5
sphingomyelin measurement
1
2
4
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
10
91.7
eosinophil percentage of leukocytes
6
90.7
0
3.1
87.9
sum of eosinophil and basophil counts
3
84.5
sphingomyelin measurement
4
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYB binding protein 1a
VGNC:9448
454446
Macaque
MYB binding protein 1a
708817
Mouse
MGI:106181
18432
Rat
RGD:62062
60571
Dog
MYB binding protein 1a
VGNC:43519
489442
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYB binding protein 1a
Macaque
MYB binding protein 1a
Mouse
Rat
Dog
MYB binding protein 1a
Publication Statistics
PubMed Score 58.03
PubMed score by year
PubTator Score 173.57
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title