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Tchem
SENP7
Sentrin-specific protease 7

Protein Summary
Description
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314261
  • ENSP00000313624
  • ENSG00000138468
  • ENST00000348610
  • ENSP00000342159
  • ENST00000394085
  • ENSP00000377647
  • ENST00000394091
  • ENSP00000377651
  • ENST00000394095
  • ENSP00000377655

Symbol
  • KIAA1707
  • SSP2
  • SUSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
cell type or tissue
0.7
transcription factor binding site profile
0.68
virus perturbation
0.64
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.99   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.99   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (47)
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.99999998
p_ni:  1.9e-8
p_wrong:  1e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
SETDB2
Tbio
Family:  TF; Epigenetic
Novelty:  0.05560622
p_int:  0.99999505
p_ni:  4.1e-8
p_wrong:  0.000004909
Score:  0.381
Data Source:  BioPlex,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.896
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.855
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.851
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.78
Data Source:  STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
Score:  0.771
Data Source:  STRINGDB
SAE1
Tbio
Novelty:  0.01613881
Score:  0.751
Data Source:  STRINGDB
SUMO4
Tbio
Novelty:  0.01534859
Score:  0.73
Data Source:  STRINGDB
NSMCE2
Tbio
Family:  Enzyme
Novelty:  0.02320995
Score:  0.729
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
87.5
IGF-1 measurement
1
2
2
79.9
alkaline phosphatase measurement
2
1
1
6.4
72.9
eosinophil count
2
1
2
71.9
eosinophil percentage of leukocytes
2
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
87.5
IGF-1 measurement
2
79.9
alkaline phosphatase measurement
1
6.4
72.9
eosinophil count
2
71.9
eosinophil percentage of leukocytes
2
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 7
VGNC:14244
740121
Macaque
SUMO1/sentrin specific peptidase 7
701453
Mouse
MGI:1913565
66315
Rat
RGD:1305510
288167
Dog
SUMO specific peptidase 7
VGNC:53087
487955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 7
Macaque
SUMO1/sentrin specific peptidase 7
Mouse
Rat
Dog
SUMO specific peptidase 7
Publication Statistics
PubMed Score 119.99
PubMed score by year
PubTator Score 9.51
PubTator score by year
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Related Publications
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PMID
Year
Title