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Tbio
SELENOS
Selenoprotein S

Protein Summary
Description
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398226
  • ENSP00000381282
  • ENSG00000131871
  • ENST00000526049
  • ENSP00000433541

Symbol
  • SELS
  • VIMP
  • SELS
  • VIMP
  • ADO15
  • SBBI8
  • SEPS1
  • AD-015
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.13   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.13   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
92.3
neutrophil percentage of leukocytes
2
2
2
88.8
myeloid white cell count
2
2
2
82.3
monocyte percentage of leukocytes
2
1
2
80.6
basophil count
2
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.3
neutrophil percentage of leukocytes
2
88.8
myeloid white cell count
2
82.3
monocyte percentage of leukocytes
2
80.6
basophil count
2
79.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein S
VGNC:6470
453691
Macaque
selenoprotein S
694752
Mouse
MGI:95994
109815
Rat
RGD:628897
286900
Dog
selenoprotein S
VGNC:45983
607791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein S
Macaque
selenoprotein S
Mouse
Rat
Dog
selenoprotein S
Protein Structure (3 Structures, 0 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (117)
1 – 10 of 117
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.999995903
p_ni:  0.000004014
p_wrong:  8.3e-8
Score:  0.495
Data Source:  BioPlex,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.999847073
p_ni:  0.00001932
p_wrong:  0.000133607
Data Source:  BioPlex
SLC22A15
Tdark
Family:  Transporter
Novelty:  0.22792289
p_int:  0.834617757
p_ni:  0.000711586
p_wrong:  0.164670657
Data Source:  BioPlex
CLCN5
Tbio
Family:  IC
Novelty:  0.00419772
p_int:  0.782024036
p_ni:  0.000653104
p_wrong:  0.217322859
Data Source:  BioPlex
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.998
Data Source:  STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.994
Data Source:  STRINGDB
SELENOK
Tbio
Novelty:  0.02182816
Score:  0.966
Data Source:  STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.951
Data Source:  STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
Score:  0.942
Data Source:  STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.936
Data Source:  STRINGDB
Publication Statistics
PubMed Score  113.13

PubMed score by year
PubTator Score  78.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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