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Tchem
TUBA1C
Tubulin alpha-1C chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301072
  • ENSP00000301072
  • ENSG00000167553

Symbol
  • TUBA6
  • TUBA6
  • bcm948
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
transcription factor binding site profile
0.97
disease perturbation
0.96
molecular function
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
85.7
self reported educational attainment
1
1
1
65.5
cognitive function measurement
2
1
2
65
platelet count
2
2
2
57
mean corpuscular hemoglobin concentration
1
1
1
52.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
85.7
self reported educational attainment
1
65.5
cognitive function measurement
2
65
platelet count
2
57
mean corpuscular hemoglobin concentration
1
52.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1095409
22146
Rat
RGD:1307226
300218
Cow
tubulin, alpha 1c
504244
Pig
tubulin alpha-1C chain
100127131
Xenopus
tubulin alpha 1c
XB-GENE-493848
394675
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
tubulin, alpha 1c
Pig
tubulin alpha-1C chain
Xenopus
tubulin alpha 1c
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQE3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Protein-Protein Interactions (149)
1 – 10 of 149
TCP11L2
Tdark
Novelty: 1.78903335
p_int: 0.999914636
p_ni: 0.000085364
Score: 0.899
Data Source: BioPlex,STRINGDB
TXNDC9
Tbio
Novelty: 0.00309772
p_int: 0.997703754
p_ni: 0.002296246
Score: 0.647
Data Source: BioPlex,STRINGDB
TUBA1B
Tchem
Novelty: 0.02465964
p_int: 0.996115761
p_ni: 0.003884239
Score: 0.995
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.981069167
p_ni: 0.018930833
Score: 0.95
Data Source: BioPlex,STRINGDB
TTC5
Tbio
Novelty: 0.12127698
p_int: 0.966911089
p_ni: 0.033088911
Score: 0.735
Data Source: BioPlex,STRINGDB
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.936601539
p_ni: 0.063398461
Data Source: BioPlex
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.890378852
p_ni: 0.109621148
Score: 0.915
Data Source: BioPlex,STRINGDB
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.792492542
p_ni: 0.207507458
Data Source: BioPlex
TPSB2
Tbio
Family: Enzyme
Novelty: 0.00757397
p_int: 0.774873993
p_ni: 0.225126007
Data Source: BioPlex
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.755480153
p_ni: 0.244519847
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  32.92

PubMed score by year
PubTator Score  4.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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