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Tclin
VKORC1
Vitamin K epoxide reductase complex subunit 1

Protein Classes
Protein Summary
Description
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative spl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319788
  • ENSP00000326135
  • ENSG00000167397
  • ENST00000354895
  • ENSP00000346969
  • ENST00000394975
  • ENSP00000378426

Symbol
  • VKOR
  • VKOR
  • MST134
  • MST576
  • VKCFD2
  • EDTP308
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
biological term
0.98
transcription factor perturbation
0.94
transcription factor binding site profile
0.84
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 776   (req: < 5)
Gene RIFs: 296   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 776   (req: >= 5)
Gene RIFs: 296   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat distribution
1
1
3
53.6
triglyceride measurement
1
1
1
18.7
snoring measurement
1
1
1
11.1
waist circumference
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat distribution
3
53.6
triglyceride measurement
1
18.7
snoring measurement
1
11.1
waist circumference
1
10.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vitamin K epoxide reductase complex subunit 1
VGNC:5952
100610370
Mouse
MGI:106442
27973
Rat
RGD:1303107
309004
Dog
vitamin K epoxide reductase complex subunit 1
VGNC:54091
479775
Cow
vitamin K epoxide reductase complex subunit 1
445422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vitamin K epoxide reductase complex subunit 1
Mouse
Rat
Dog
vitamin K epoxide reductase complex subunit 1
Cow
vitamin K epoxide reductase complex subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQB6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamin K
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamin K
Metabolism of vitamins and cofactors
Protein-Protein Interactions (51)
1 – 10 of 51
TMPRSS11B
Tdark
Family: Enzyme
Novelty: 1.20690443
p_int: 0.999767526
p_ni: 0.000006126
p_wrong: 0.000226348
Score: 0.237
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.870738329
p_ni: 0.002733008
p_wrong: 0.126528663
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.782095465
p_ni: 0.000209353
p_wrong: 0.217695182
Data Source: BioPlex
GGCX
Tclin
Family: Enzyme
Novelty: 0.00819484
Score: 0.991
Data Source: STRINGDB
NQO1
Tchem
Family: Enzyme
Novelty: 0.00055755
Score: 0.939
Data Source: STRINGDB
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.925
Data Source: STRINGDB
CYP4F2
Tchem
Family: Enzyme
Novelty: 0.0050361
Score: 0.921
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.788
Data Source: STRINGDB
TPMT
Tchem
Family: Enzyme
Novelty: 0.00272111
Score: 0.733
Data Source: STRINGDB
ABCC6
Tbio
Family: Transporter
Novelty: 0.0032341
Score: 0.714
Data Source: STRINGDB
Publication Statistics
PubMed Score  776.00

PubMed score by year
PubTator Score  618.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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