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Tdark
CYBC1
Cytochrome b-245 chaperone 1

Protein Summary
Description
Necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 hetrodimer. Controls the phagocyte respiratory burst and is essential for innate immunity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306645
  • ENSP00000307765
  • ENSG00000178927
  • ENST00000434650
  • ENSP00000401626
  • ENST00000437807
  • ENSP00000388909
  • ENST00000577436
  • ENSP00000464633
  • ENST00000577732
  • ENSP00000463228
  • ENST00000578919
  • ENSP00000464080
  • ENST00000585064
  • ENSP00000463846
  • ENST00000585080
  • ENSP00000462529

Symbol
  • C17orf62
  • EROS
  • Eros
  • C17orf62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
p_int:  0.999979184
p_ni:  0.000020769
p_wrong:  4.7e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
GTF2A1
Tchem
Novelty:  0.19577296
p_int:  0.999927929
p_ni:  0.000072045
p_wrong:  2.7e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999687343
p_ni:  0.000268796
p_wrong:  0.000043861
Data Source:  BioPlex
TMEM126A
Tbio
Novelty:  0.11759225
Score:  0.765
Data Source:  STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
Score:  0.73
Data Source:  STRINGDB
DHRS7
Tbio
Family:  Enzyme
Novelty:  0.16713756
Score:  0.716
Data Source:  STRINGDB
TMEM41A
Tdark
Novelty:  1.49362751
Score:  0.715
Data Source:  STRINGDB
TMEM38A
Tbio
Family:  IC
Novelty:  0.10891929
Score:  0.709
Data Source:  STRINGDB
ANKMY1
Tbio
Novelty:  0.15068511
Score:  0.692
Data Source:  STRINGDB
TMEM209
Tdark
Novelty:  0.3422324
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
2
3
83.4
red blood cell distribution width
4
1
4
81.9
mean corpuscular hemoglobin concentration
1
1
1
73.2
reticulocyte measurement
2
1
2
72.6
mean platelet volume
2
2
2
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
83.4
red blood cell distribution width
4
81.9
mean corpuscular hemoglobin concentration
1
73.2
reticulocyte measurement
2
72.6
mean platelet volume
2
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chromosome 16 open reading frame, human C17orf62
716212
Mouse
MGI:2384959
217370
Rat
RGD:1562022
619574
Dog
cytochrome b-245 chaperone 1
VGNC:52590
608239
Horse
cytochrome b-245 chaperone 1
VGNC:51359
100056149
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chromosome 16 open reading frame, human C17orf62
Mouse
Rat
Dog
cytochrome b-245 chaperone 1
Horse
cytochrome b-245 chaperone 1
Publication Statistics
PubMed Score 1.30
PubMed score by year
PubTator Score 1.35
PubTator score by year
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Related Publications
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PMID
Year
Title