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Tbio
HINFP
Histone H4 transcription factor

Protein Summary
Description
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350777
  • ENSP00000318085
  • ENSG00000172273
  • ENST00000527410
  • ENSP00000436815

Symbol
  • MIZF
  • ZNF743
  • MIZF
  • HiNF-P
  • ZNF743
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
biological process
0.79
molecular function
0.79
transcription factor binding site profile
0.73
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.04   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.04   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (35)
1 – 10 of 35
MECP2
Tchem
Family: TF
Novelty: 0.00051767
Score: 0.845
Data Source: STRINGDB
NPAT
Tbio
Novelty: 0.01063979
Score: 0.777
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.732
Data Source: STRINGDB
HIST1H4G
Tdark
Novelty: 1.72429907
Score: 0.728
Data Source: STRINGDB
HMX3
Tbio
Family: TF
Novelty: 0.05995617
Score: 0.711
Data Source: STRINGDB
HMX1
Tbio
Family: TF
Novelty: 0.03754742
Score: 0.711
Data Source: STRINGDB
HMX2
Tbio
Family: TF
Novelty: 0.02119921
Score: 0.711
Data Source: STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
Score: 0.618
Data Source: STRINGDB
FOXI1
Tbio
Family: TF
Novelty: 0.02247223
Score: 0.577
Data Source: STRINGDB
SLC35B2
Tbio
Family: Transporter
Novelty: 0.01516638
Score: 0.545
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.04

PubMed score by year
PubTator Score  12.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer