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Tbio
WDR77
Methylosome protein 50

Protein Summary
Description
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being n ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235090
  • ENSP00000235090
  • ENSG00000116455

Symbol
  • MEP50
  • WD45
  • p44
  • MEP50
  • MEP-50
  • HKMT1069
  • Nbla10071
  • p44/Mep50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.87
ligand (protein) perturbation
0.83
hub protein
0.82
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.998321594
p_ni:  0.001678406
Score:  0.195
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.994533117
p_ni:  0.005466883
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.992008827
p_ni:  0.007991173
Score:  0.227
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.990307197
p_ni:  0.009692803
Score:  0.625
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.984086764
p_ni:  0.015913236
Score:  0.152
Data Source:  BioPlex,STRINGDB
PPP1R14A
Tbio
Family:  Enzyme
Novelty:  0.00231198
p_int:  0.983136457
p_ni:  0.016863543
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.982989773
p_ni:  0.017010227
Score:  0.306
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.9770957
p_ni:  0.0229043
Score:  0.966
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.96013796
p_ni:  0.03986204
Score:  0.388
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.950323663
p_ni:  0.049676337
Score:  0.491
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Metabolism of RNA
Metabolism of non-coding RNA
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake measurement
1
1
0
145
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake measurement
0
145
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 77
VGNC:1634
744535
Macaque
WD repeat domain 77
677686
Mouse
MGI:1917715
70465
Dog
WD repeat domain 77
479902
Horse
WD repeat domain 77
VGNC:25018
100058858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 77
Macaque
WD repeat domain 77
Mouse
Dog
WD repeat domain 77
Horse
WD repeat domain 77
Publication Statistics
PubMed Score 39.10
PubMed score by year
PubTator Score 22.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title