Tbio ECSIT Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Protein Summary

Description

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

Uniprot Accession IDs

• Q9BQ95
• E9PAN9
• K7EMM0
• Q96HQ7
• Q9NYI1

Gene Name

• ECSIT

Ensembl ID

• ENST00000252440
• ENSP00000252440
• ENSG00000130159
• ENST00000270517
• ENSP00000270517
• ENST00000417981
• ENSP00000412712
• ENST00000591104
• ENSP00000466559

Symbol

• SITPEC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.92
protein complex	0.81
cell type or tissue	0.77
histone modification site profile	0.76
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0