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Tbio
ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Protein Summary
Description
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252440
  • ENSP00000252440
  • ENSG00000130159
  • ENST00000270517
  • ENSP00000270517
  • ENST00000417981
  • ENSP00000412712
  • ENST00000591104
  • ENSP00000466559

Symbol
  • SITPEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
protein complex
0.81
cell type or tissue
0.77
histone modification site profile
0.76
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.999999998
p_ni:  2e-9
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
NDUFAF1
Tclin
Novelty:  0.05630549
p_int:  0.99999403
p_ni:  0.00000597
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999990211
p_ni:  0.000009789
Score:  0.284
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.999976669
p_ni:  0.000023331
Score:  0.974
Data Source:  BioPlex,STRINGDB
NDUFB1
Tclin
Family:  Enzyme
Novelty:  0.08981517
p_int:  0.999841407
p_ni:  0.0001325
p_wrong:  0.000026093
Score:  0.98
Data Source:  BioPlex,STRINGDB
NDUFC2
Tclin
Family:  Enzyme
Novelty:  0.08387385
p_int:  0.999824203
p_ni:  0.000175796
Score:  0.981
Data Source:  BioPlex,STRINGDB
COA1
Tbio
Family:  Enzyme
Novelty:  0.49194068
p_int:  0.999819702
p_ni:  0.000180291
p_wrong:  6e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999212916
p_ni:  0.000787084
Data Source:  BioPlex
MGME1
Tbio
Family:  Enzyme
Novelty:  0.05284418
p_int:  0.99905882
p_ni:  0.00094118
Score:  0.782
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.999035705
p_ni:  0.000964295
Score:  0.983
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
MyD88 cascade initiated on plasma membrane
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Immune System
Innate Immune System
Metabolism
MyD88 cascade initiated on plasma membrane
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
4
2
4
95.5
3
1
1
7.8
83
blood protein measurement
1
2
2
75.5
mean arterial pressure
2
1
2
74.3
systolic blood pressure
2
1
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
4
95.5
1
7.8
83
blood protein measurement
2
75.5
mean arterial pressure
2
74.3
systolic blood pressure
2
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ECSIT signalling integrator
714805
Mouse
MGI:1349469
26940
Rat
RGD:1359488
300447
Dog
ECSIT signalling integrator
VGNC:40188
484938
Horse
ECSIT signalling integrator
VGNC:17411
100054814
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ECSIT signalling integrator
Mouse
Rat
Dog
ECSIT signalling integrator
Horse
ECSIT signalling integrator
Publication Statistics
PubMed Score 30.48
PubMed score by year
PubTator Score 8.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text