Tbio SLX1A Structure-specific endonuclease subunit SLX1

Protein Summary

Description

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9BQ83
• B7ZME1
• Q6NTG6

Gene Name

• SLX1A

Ensembl ID

• ENST00000251303
• ENSP00000251303
• ENSG00000132207
• ENST00000330181
• ENSP00000328940
• ENSG00000181625
• ENST00000345535
• ENSP00000333945
• ENST00000351581
• ENSP00000335316

Symbol

• GIYD1
• SLX1
• GIYD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.73
cell line	0.71
transcription factor binding site profile	0.46
interacting protein	0.43
protein complex	0.41

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endodeoxyribonuclease / Structure-specific Endonuclease Subunit Slx1

Protein / Nucleic Acid Binding / Dna Binding Protein / Endodeoxyribonuclease / Structure-specific Endonuclease Subunit Slx1

DTO Classes

Protein / Enzyme / Nuclease / Endodeoxyribonuclease / Structure-specific Endonuclease Subunit Slx1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.24   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.24   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0