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Tbio
SLX1A
Structure-specific endonuclease subunit SLX1

Protein Summary
Description
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251303
  • ENSP00000251303
  • ENSG00000132207
  • ENST00000330181
  • ENSP00000328940
  • ENSG00000181625
  • ENST00000345535
  • ENSP00000333945
  • ENST00000351581
  • ENSP00000335316

Symbol
  • GIYD1
  • SLX1
  • GIYD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell line
0.71
transcription factor binding site profile
0.46
interacting protein
0.43
protein complex
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
GPBP1
Tbio
Novelty:  0.18802498
p_int:  0.999998115
p_ni:  0.000001522
p_wrong:  3.63e-7
Data Source:  BioPlex
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999797909
p_ni:  0.000202086
p_wrong:  5e-9
Data Source:  BioPlex
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.998979353
p_ni:  0.001020646
p_wrong:  1e-9
Data Source:  BioPlex
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.997630701
p_ni:  0.002369299
Data Source:  BioPlex
MAP3K21
Tbio
Family:  Kinase
Novelty:  0.14070877
p_int:  0.99759516
p_ni:  0.000026645
p_wrong:  0.002378195
Data Source:  BioPlex
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
p_int:  0.997457677
p_ni:  0.001031893
p_wrong:  0.00151043
Data Source:  BioPlex
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.989877599
p_ni:  0.010122401
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.989792789
p_ni:  0.009067418
p_wrong:  0.001139793
Data Source:  BioPlex
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
p_int:  0.966381679
p_ni:  0.032560268
p_wrong:  0.001058053
Data Source:  BioPlex
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.921983807
p_ni:  0.074609101
p_wrong:  0.003407092
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Fanconi Anemia Pathway
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
34.9
diastolic blood pressure
1
1
1
14.1
1
1
0
1.1
9.3
1
1
0
1.2
0.2
tonsillectomy risk measurement
1
1
0
1.1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
34.9
diastolic blood pressure
1
14.1
0
1.1
9.3
0
1.2
0.2
tonsillectomy risk measurement
0
1.1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915220
75764
Rat
RGD:1311568
293489
Dog
SLX1 homolog A, structure-specific endonuclease subunit
607780
Cow
SLX1 homolog A, structure-specific endonuclease subunit
510858
Fruitfly
FBgn0037263
40578
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SLX1 homolog A, structure-specific endonuclease subunit
Cow
SLX1 homolog A, structure-specific endonuclease subunit
Fruitfly
Publication Statistics
PubMed Score 25.62
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title