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Tbio
TCF25
Transcription factor 25

Protein Summary
Description
May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263346
  • ENSP00000263346
  • ENSG00000141002
  • ENST00000640279
  • ENSP00000491638

Symbol
  • KIAA1049
  • NULP1
  • Hulp1
  • NULP1
  • FKSG26
  • PRO2620
  • hKIAA1049
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.98
virus perturbation
0.97
histone modification site profile
0.82
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
94.1
hair color
2
6
0
2.7
93.9
synophrys measurement
1
1
1
44.8
white matter integrity
1
1
1
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
94.1
hair color
0
2.7
93.9
synophrys measurement
1
44.8
white matter integrity
1
38.5
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
GPRASP2
Tbio
Novelty: 0.14060209
p_int: 0.999968934
p_ni: 0.000031066
Score: 0.862
Data Source: BioPlex,STRINGDB
BCKDHB
Tbio
Family: Enzyme
Novelty: 0.02234969
p_int: 0.996191002
p_ni: 0.003586261
p_wrong: 0.000222737
Score: 0.189
Data Source: BioPlex,STRINGDB
DCAF5
Tdark
Novelty: 0.39565074
p_int: 0.993408399
p_ni: 0.0065916
Data Source: BioPlex
SHPK
Tbio
Family: Kinase
Novelty: 0.16166855
p_int: 0.988545725
p_ni: 0.011454275
Score: 0.209
Data Source: BioPlex,STRINGDB
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
p_int: 0.935528141
p_ni: 0.064471859
Score: 0.175
Data Source: BioPlex,STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
p_int: 0.930688229
p_ni: 0.069311771
Score: 0.787
Data Source: BioPlex,STRINGDB
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.914973642
p_ni: 0.085026358
Data Source: BioPlex
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.897966183
p_ni: 0.102033817
Data Source: BioPlex
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.865352592
p_ni: 0.134647408
Data Source: BioPlex
PPAN
Tbio
Novelty: 0.01063709
p_int: 0.829292651
p_ni: 0.170707349
Data Source: BioPlex
Publication Statistics
PubMed Score  10.80

PubMed score by year
PubTator Score  3.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer