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Tbio
GRWD1
Glutamate-rich WD repeat-containing protein 1

Protein Summary
Description
Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253237
  • ENSP00000253237
  • ENSG00000105447

Symbol
  • GRWD
  • KIAA1942
  • WDR28
  • CDW4
  • GRWD
  • RRB1
  • WDR28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
histone modification site profile
0.91
disease perturbation
0.9
transcription factor binding site profile
0.89
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (300)
1 – 10 of 300
BOP1
Tbio
Novelty:  0.03512044
Score:  0.995
Data Source:  STRINGDB
WDR36
Tbio
Novelty:  0.02010676
Score:  0.993
Data Source:  STRINGDB
NOC2L
Tbio
Novelty:  0.00226536
Score:  0.989
Data Source:  STRINGDB
DDX56
Tbio
Family:  Enzyme
Novelty:  0.03330582
Score:  0.987
Data Source:  STRINGDB
GTPBP4
Tchem
Novelty:  0.00062563
Score:  0.987
Data Source:  STRINGDB
DDX18
Tbio
Family:  Enzyme
Novelty:  0.07900572
Score:  0.985
Data Source:  STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
Score:  0.981
Data Source:  STRINGDB
NOL10
Tdark
Novelty:  0.27358884
Score:  0.978
Data Source:  STRINGDB
PES1
Tbio
Novelty:  0.07162845
Score:  0.961
Data Source:  STRINGDB
RBM19
Tbio
Novelty:  0.15784228
Score:  0.959
Data Source:  STRINGDB
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate rich WD repeat containing 1
VGNC:11124
468939
Macaque
glutamate rich WD repeat containing 1
717966
Mouse
MGI:2141989
101612
Rat
RGD:1310649
308592
Dog
glutamate rich WD repeat containing 1
VGNC:41521
612058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate rich WD repeat containing 1
Macaque
glutamate rich WD repeat containing 1
Mouse
Rat
Dog
glutamate rich WD repeat containing 1
Publication Statistics
PubMed Score 13.61
PubMed score by year
PubTator Score 5.36
PubTator score by year