You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TRIR
Telomerase RNA component interacting RNase

Protein Summary
Description
Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242784
  • ENSP00000242784
  • ENSG00000123144

Symbol
  • C19orf43
  • TERCIR
  • fSAP18
  • C19orf43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
82.5
mean corpuscular volume
1
1
1
54.4
cathepsin L1 measurement
1
1
1
42.3
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
82.5
mean corpuscular volume
1
54.4
cathepsin L1 measurement
1
42.3
1
8.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomerase RNA component interacting RNase
VGNC:3658
455749
Macaque
telomerase RNA component interacting RNase
716466
Mouse
MGI:1922833
68544
Rat
RGD:1564093
288920
Dog
telomerase RNA component interacting RNase
VGNC:54381
476700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomerase RNA component interacting RNase
Macaque
telomerase RNA component interacting RNase
Mouse
Rat
Dog
telomerase RNA component interacting RNase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQ61-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (20)
1 – 10 of 20
SNRPA
Tbio
Novelty:  0.00184221
Score:  0.779
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.748
Data Source:  STRINGDB
SPRN
Tbio
Novelty:  0.02906105
Score:  0.686
Data Source:  STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
Score:  0.669
Data Source:  STRINGDB
WRNIP1
Tbio
Family:  Enzyme
Novelty:  0.04923448
Score:  0.666
Data Source:  STRINGDB
TRIL
Tbio
Novelty:  0.0179925
Score:  0.638
Data Source:  STRINGDB
FLNC
Tbio
Novelty:  0.00463205
Score:  0.635
Data Source:  STRINGDB
THUMPD1
Tdark
Novelty:  0.19420931
Score:  0.587
Data Source:  STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
Score:  0.533
Data Source:  STRINGDB
SPAG17
Tdark
Novelty:  0.03260168
Score:  0.53
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.26

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer