You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ELAC2
Zinc phosphodiesterase ELAC protein 2

Protein Summary
Description
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338034
  • ENSP00000337445
  • ENSG00000006744
  • ENST00000426905
  • ENSP00000405223

Symbol
  • HPC2
  • ELC2
  • HPC2
  • COXPD17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.9
gene perturbation
0.85
virus perturbation
0.79
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.2   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.2   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.999779462
p_ni:  0.000220538
Score:  0.669
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.998163112
p_ni:  0.001836888
Score:  0.586
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.955869285
p_ni:  0.044130715
Score:  0.337
Data Source:  BioPlex,STRINGDB
TRMT10C
Tbio
Family:  Enzyme
Novelty:  0.07045719
p_int:  0.937680725
p_ni:  0.062319275
Score:  0.924
Data Source:  BioPlex,STRINGDB
MRPL21
Tdark
Novelty:  0.56552559
p_int:  0.898595994
p_ni:  0.101404006
Score:  0.223
Data Source:  BioPlex,STRINGDB
RRP12
Tbio
Novelty:  0.10034381
Score:  0.889
Data Source:  STRINGDB
CKAP5
Tbio
Novelty:  0.00623771
Score:  0.875
Data Source:  STRINGDB
ELAC1
Tbio
Family:  Enzyme
Novelty:  0.05322007
Score:  0.862
Data Source:  STRINGDB
TBL3
Tdark
Novelty:  0.05195885
Score:  0.861
Data Source:  STRINGDB
TRNT1
Tbio
Family:  Enzyme
Novelty:  0.00509556
Score:  0.84
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Reactome
tRNA processing
Reactome
tRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA processing
rRNA processing in the mitochondrion
tRNA processing
tRNA processing in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elaC ribonuclease Z 2
VGNC:9459
450109
Macaque
elaC ribonuclease Z 2
718217
Mouse
MGI:1890496
68626
Rat
RGD:628882
282826
Dog
elaC ribonuclease Z 2
VGNC:40296
489511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elaC ribonuclease Z 2
Macaque
elaC ribonuclease Z 2
Mouse
Rat
Dog
elaC ribonuclease Z 2
Publication Statistics
PubMed Score 84.20
PubMed score by year
PubTator Score 45.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title