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Tchem
PDCD1LG2
Programmed cell death 1 ligand 2

Protein Summary
Description
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397747
  • ENSP00000380855
  • ENSG00000197646

Symbol
  • B7DC
  • CD273
  • PDCD1L2
  • PDL2
  • B7DC
  • Btdc
  • PDL2
  • CD273
  • PD-L2
  • PDCD1L2
  • bA574F11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cell type or tissue
0.7
biological term
0.59
microRNA
0.59
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.99   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 859   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.99   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0