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Tbio
TREX2
Three prime repair exonuclease 2

Protein Summary
Description
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330912
  • ENSP00000333441
  • ENSG00000183479
  • ENST00000334497
  • ENSP00000334993
  • ENST00000338525
  • ENSP00000345218
  • ENST00000370212
  • ENSP00000359231
  • ENST00000370231
  • ENSP00000359251
  • ENST00000370232
  • ENSP00000359252
  • ENST00000393862
  • ENSP00000377442
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
molecular function
0.84
disease perturbation
0.79
cell type or tissue
0.67
co-expressed gene
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
84.4
balding measurement
1
1
1
79.8
Alopecia
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
84.4
balding measurement
1
79.8
Alopecia
1
38.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346343
24102
Rat
RGD:1562245
309275
Dog
three prime repair exonuclease 2
VGNC:54379
492236
Horse
three prime repair exonuclease 2
VGNC:24487
100057632
Opossum
three prime repair exonuclease 2-like
100013741
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
three prime repair exonuclease 2
Horse
three prime repair exonuclease 2
Opossum
three prime repair exonuclease 2-like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BQ50-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (17)
1 – 10 of 17
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.999973192
p_ni:  0.000019361
p_wrong:  0.000007447
Score:  0.252
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.999895575
p_ni:  0.000104425
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999777166
p_ni:  0.000129759
p_wrong:  0.000093076
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999638158
p_ni:  0.000225446
p_wrong:  0.000136395
Score:  0.201
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999631238
p_ni:  0.000109463
p_wrong:  0.000259299
Score:  0.208
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.99825827
p_ni:  0.001428619
p_wrong:  0.000313111
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.992245093
p_ni:  0.000318259
p_wrong:  0.007436649
Data Source:  BioPlex
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.942185758
p_ni:  0.014353457
p_wrong:  0.043460785
Data Source:  BioPlex
HAUS7
Tbio
Novelty:  1.11657571
Score:  0.847
Data Source:  STRINGDB
BLM
Tchem
Novelty:  0.00662454
Score:  0.584
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.18

PubMed score by year
PubTator Score  27.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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