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Tdark
MRPL34
39S ribosomal protein L34, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252602
  • ENSP00000252602
  • ENSG00000130312
  • ENST00000594999
  • ENSP00000471820
  • ENST00000600434
  • ENSP00000469581

Symbol
  • L34mt
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
kinase perturbation
0.88
transcription factor binding site profile
0.87
disease perturbation
0.68
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
1
1
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
55.6
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2137227
94065
Rat
RGD:1359397
290632
Dog
mitochondrial ribosomal protein L34
610139
Horse
mitochondrial ribosomal protein L34
100630373
Cow
mitochondrial ribosomal protein L34
786454
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial ribosomal protein L34
Horse
mitochondrial ribosomal protein L34
Cow
mitochondrial ribosomal protein L34
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BQ48-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (149)
1 – 10 of 149
RANBP6
Tdark
Novelty: 0.75714796
p_int: 0.999987516
p_ni: 0.000012484
Data Source: BioPlex
IPO5
Tbio
Novelty: 0.00452607
p_int: 0.999966928
p_ni: 0.000033069
p_wrong: 3e-9
Score: 0.562
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
p_int: 0.99986958
p_ni: 0.000099985
p_wrong: 0.000030435
Data Source: BioPlex
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999755258
p_ni: 0.000244742
Score: 0.997
Data Source: BioPlex,STRINGDB
UTP11
Tbio
Novelty: 0.20711838
p_int: 0.999691257
p_ni: 0.000210801
p_wrong: 0.000097942
Score: 0.234
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.999490522
p_ni: 0.000509478
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999358321
p_ni: 0.000641678
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.999343769
p_ni: 0.000656231
Score: 0.969
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.999275837
p_ni: 0.000724163
Score: 0.986
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.995416585
p_ni: 0.004583414
Score: 0.988
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.26

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer