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Tbio
DDX50
ATP-dependent RNA helicase DDX50

Protein Summary
Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373585
  • ENSP00000362687
  • ENSG00000107625

Symbol
  • GU2
  • GUB
  • mcdrh
  • RH-II/GuB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.96
interacting protein
0.95
molecular function
0.94
histone modification site profile
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (186)
1 – 10 of 186
CHCHD2
Tbio
Novelty: 0.02070317
p_int: 0.999949676
p_ni: 5.28e-7
p_wrong: 0.000049796
Data Source: BioPlex
PHF10
Tbio
Family: Epigenetic
Novelty: 0.06950506
p_int: 0.999806242
p_ni: 0.000193757
p_wrong: 1e-9
Data Source: BioPlex
ZNF579
Tdark
Family: TF
p_int: 0.998539053
p_ni: 0.001460947
Data Source: BioPlex
ZNF638
Tbio
Novelty: 0.18775145
p_int: 0.995674982
p_ni: 0.004325018
Data Source: BioPlex
GID4
Tbio
Novelty: 0.10469899
p_int: 0.989891991
p_ni: 0.010108009
Data Source: BioPlex
CACTIN
Tbio
Novelty: 0.05639339
p_int: 0.98868111
p_ni: 0.009760833
p_wrong: 0.001558056
Data Source: BioPlex
DDX21
Tbio
Family: Enzyme
Novelty: 0.00446097
p_int: 0.983456668
p_ni: 0.016543332
Score: 0.526
Data Source: BioPlex,STRINGDB
C1QBP
Tbio
Novelty: 0.00278686
p_int: 0.982895719
p_ni: 0.017104281
Data Source: BioPlex
DHX57
Tdark
Family: Enzyme
Novelty: 1.71428571
p_int: 0.980860764
p_ni: 0.019139236
Score: 0.498
Data Source: BioPlex,STRINGDB
ZFP91
Tbio
Family: TF
Novelty: 0.02001763
p_int: 0.970769122
p_ni: 0.027666302
p_wrong: 0.001564576
Data Source: BioPlex
Publication Statistics
PubMed Score  14.69

PubMed score by year
PubTator Score  10.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer