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Tclin
KCNS3
Potassium voltage-gated channel subfamily S member 3

Protein Summary
Description
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subuni ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304101
  • ENSP00000305824
  • ENSG00000170745
  • ENST00000403915
  • ENSP00000385968

Symbol
  • KV9.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.86
trait
0.86
histone modification site profile
0.76
PubMedID
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
2
90.2
forced expiratory volume
2
3
3
87
testosterone measurement
1
1
1
61.7
body fat percentage
1
1
1
58.8
peak expiratory flow
1
2
2
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
90.2
forced expiratory volume
3
87
testosterone measurement
1
61.7
body fat percentage
1
58.8
peak expiratory flow
2
45.1
Pathways (7)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Metabolism
Neuronal System
Potassium Channels
Protein-Protein Interactions (176)
1 – 10 of 176
SUCO
Tdark
Novelty: 0.00074481
p_int: 0.999999092
p_ni: 9.08e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
TAPT1
Tbio
Novelty: 0.12057711
p_int: 0.999854197
p_ni: 0.000127357
p_wrong: 0.000018446
Score: 0.167
Data Source: BioPlex,STRINGDB
KCNQ5
Tclin
Family: IC
Novelty: 0.01271842
p_int: 0.999684652
p_ni: 0.000293336
p_wrong: 0.000022012
Score: 0.335
Data Source: BioPlex,STRINGDB
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
p_int: 0.999538766
p_ni: 0.000461234
p_wrong: 1e-9
Data Source: BioPlex
C2CD2L
Tbio
Novelty: 0.2051681
p_int: 0.999408644
p_ni: 0.000591328
p_wrong: 2.8e-8
Data Source: BioPlex
C1orf43
Tbio
Novelty: 0.13587458
p_int: 0.999056394
p_ni: 0.000943606
Data Source: BioPlex
KCNB2
Tclin
Family: IC
Novelty: 0.02629102
p_int: 0.99704674
p_ni: 9.8e-8
p_wrong: 0.002953162
Score: 0.299
Data Source: BioPlex,STRINGDB
PDZD8
Tbio
Novelty: 0.09015543
p_int: 0.997000715
p_ni: 0.002999285
Data Source: BioPlex
DNAJC18
Tdark
Novelty: 1.38573997
p_int: 0.996038982
p_ni: 0.003961008
p_wrong: 9e-9
Data Source: BioPlex
REEP4
Tbio
Novelty: 0.37950931
p_int: 0.996023654
p_ni: 0.003975795
p_wrong: 5.51e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.97

PubMed score by year
PubTator Score  9.98

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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