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Tbio
NABP2
SOSS complex subunit B1

Protein Summary
Description
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267023
  • ENSP00000267023
  • ENSG00000139579
  • ENST00000341463
  • ENSP00000368862
  • ENST00000380198
  • ENSP00000369545

Symbol
  • OBFC2B
  • SSB1
  • SSB1
  • hSSB1
  • OBFC2B
  • SOSS-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.86
cell type or tissue
0.83
transcription factor binding site profile
0.74
transcription factor perturbation
0.74
transcription factor
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917167
69917
Rat
RGD:1308158
362813
Dog
nucleic acid binding protein 2
VGNC:43602
474400
Horse
nucleic acid binding protein 2
VGNC:20540
100052155
Cow
nucleic acid binding protein 2
VGNC:31860
533842
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nucleic acid binding protein 2
Horse
nucleic acid binding protein 2
Cow
nucleic acid binding protein 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BQ15-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Protein-Protein Interactions (118)
1 – 10 of 118
INIP
Tbio
Novelty: 0.08511211
p_int: 0.999999996
p_ni: 3e-9
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
INTS3
Tbio
Novelty: 0.13398603
p_int: 0.999999848
p_ni: 1.52e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
INTS6L
Tdark
Novelty: 1.91229606
p_int: 0.999999772
p_ni: 2.05e-7
p_wrong: 2.2e-8
Data Source: BioPlex
INTS9
Tbio
Novelty: 0.06037786
p_int: 0.999998125
p_ni: 0.000001874
p_wrong: 1e-9
Score: 0.945
Data Source: BioPlex,STRINGDB
INTS6
Tbio
Novelty: 0.02680242
p_int: 0.999908377
p_ni: 0.000091623
Score: 0.999
Data Source: BioPlex,STRINGDB
INTS8
Tdark
Novelty: 0.03933008
p_int: 0.9993821
p_ni: 0.000617899
p_wrong: 1e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
INTS5
Tbio
Novelty: 0.02127142
p_int: 0.997713737
p_ni: 0.002286262
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
PRTFDC1
Tbio
Family: Enzyme
Novelty: 0.13607881
p_int: 0.994267989
p_ni: 0.000385077
p_wrong: 0.005346934
Data Source: BioPlex
BIRC6
Tbio
Novelty: 0.01187953
p_int: 0.994255667
p_ni: 0.005744333
Data Source: BioPlex
FBXW5
Tbio
Novelty: 0.13100873
p_int: 0.98856269
p_ni: 0.000564028
p_wrong: 0.010873281
Data Source: BioPlex
Publication Statistics
PubMed Score  13.52

PubMed score by year
PubTator Score  25.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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