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Tbio
MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1

Protein Summary
Description
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphoryl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265960
  • ENSP00000265960
  • ENSG00000119487
  • ENST00000350766
  • ENSP00000265961
  • ENST00000373498
  • ENSP00000362597
  • ENST00000373503
  • ENSP00000362602
  • ENST00000373511
  • ENSP00000362610
  • ENST00000394060
  • ENSP00000377624
  • ENST00000394063
  • ENSP00000377627

Symbol
  • MIP1
  • SIN1
  • MIP1
  • SIN1
  • JC310
  • SIN1b
  • SIN1g
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.83
transcription factor perturbation
0.8
virus perturbation
0.79
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.02   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.02   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.1
mathematical ability
1
1
1
48.6
sleep duration
1
1
1
44.7
smoking behaviour measurement
1
1
1
34.7
systolic blood pressure
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.1
mathematical ability
1
48.6
sleep duration
1
44.7
smoking behaviour measurement
1
34.7
systolic blood pressure
1
13.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase associated protein 1
VGNC:8907
464736
Macaque
mitogen-activated protein kinase associated protein 1
702599
Mouse
MGI:2444554
227743
Rat
RGD:1305363
296648
Dog
mitogen-activated protein kinase associated protein 1
VGNC:43005
480724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase associated protein 1
Macaque
mitogen-activated protein kinase associated protein 1
Mouse
Rat
Dog
mitogen-activated protein kinase associated protein 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (57)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by AKT1 E17K in Cancer
Costimulation by the CD28 family
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (80)
1 – 10 of 80
MLST8
Tbio
Novelty: 0.00423122
Score: 0.999
Data Source: STRINGDB
RICTOR
Tbio
Novelty: 0.00250734
Score: 0.999
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: STRINGDB
SGK1
Tchem
Family: Kinase
Novelty: 0.00155681
Score: 0.977
Data Source: STRINGDB
PRR5
Tbio
Novelty: 0.03269368
Score: 0.977
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.977
Data Source: STRINGDB
DEPTOR
Tbio
Novelty: 0.01419675
Score: 0.976
Data Source: STRINGDB
TSC2
Tbio
Novelty: 0.00067416
Score: 0.974
Data Source: STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
Score: 0.973
Data Source: STRINGDB
TSC1
Tbio
Novelty: 0.00406614
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.02

PubMed score by year
PubTator Score  597.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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