Tbio PAIP2 Polyadenylate-binding protein-interacting protein 2

Protein Summary

Description

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Uniprot Accession IDs

• Q9BPZ3
• B2RBI1
• D3DQC6
• Q49A06
• Q9H0Y5
• Q9P0Q8
• PABP-interacting protein 2

Gene Name

• PAIP2

Ensembl ID

• ENST00000265192
• ENSP00000265192
• ENSG00000120727
• ENST00000394795
• ENSP00000378275
• ENST00000510080
• ENSP00000422508

Symbol

• PAIP2A
• PAIP-2
• PAIP2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.94
small molecule perturbation	0.88
transcription factor binding site profile	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.41   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.41   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0