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Tbio
PAIP2
Polyadenylate-binding protein-interacting protein 2

Protein Summary
Description
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265192
  • ENSP00000265192
  • ENSG00000120727
  • ENST00000394795
  • ENSP00000378275
  • ENST00000510080
  • ENSP00000422508

Symbol
  • PAIP2A
  • PAIP-2
  • PAIP2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
small molecule perturbation
0.88
transcription factor binding site profile
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.947013565
p_ni:  0.052967257
p_wrong:  0.000019178
Score:  0.201
Data Source:  BioPlex,STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.946053174
p_ni:  0.053946739
p_wrong:  8.7e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.929113825
p_ni:  0.06200665
p_wrong:  0.008879526
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.929113825
p_ni:  0.06200665
p_wrong:  0.008879526
Data Source:  BioPlex
PAIP1
Tbio
Novelty:  0.05922084
p_int:  0.808405159
p_ni:  0.191594808
p_wrong:  3.3e-8
Score:  0.872
Data Source:  BioPlex,STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.995
Data Source:  STRINGDB
PABPC4
Tbio
Novelty:  0.06854984
Score:  0.931
Data Source:  STRINGDB
PABPC5
Tdark
Novelty:  0.36077159
Score:  0.891
Data Source:  STRINGDB
PABPC1L
Tbio
Novelty:  0.04037574
Score:  0.865
Data Source:  STRINGDB
PABPC3
Tbio
Novelty:  0.13551529
Score:  0.859
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
viral load
1
1
1
66.8
electrocardiography
1
1
4
62.1
reticulocyte count
1
1
1
49.5
reticulocyte measurement
2
1
2
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
viral load
1
66.8
electrocardiography
4
62.1
reticulocyte count
1
49.5
reticulocyte measurement
2
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein interacting protein 2
VGNC:4115
462103
Mouse
MGI:1915119
67869
Rat
RGD:1359176
361309
Dog
poly(A) binding protein interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:17970]
Horse
poly(A) binding protein interacting protein 2
100062144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein interacting protein 2
Mouse
Rat
Dog
poly(A) binding protein interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:17970]
Horse
poly(A) binding protein interacting protein 2
Publication Statistics
PubMed Score 19.73
PubMed score by year
PubTator Score 18.23
PubTator score by year
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Related Publications
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PMID
Year
Title