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Tbio
HOPX
Homeodomain-only protein

Protein Summary
Description
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317745
  • ENSP00000315198
  • ENSG00000171476
  • ENST00000337881
  • ENSP00000337330
  • ENST00000381255
  • ENSP00000370654
  • ENST00000381260
  • ENSP00000370659
  • ENST00000420433
  • ENSP00000396275
  • ENST00000503639
  • ENSP00000424101
  • ENST00000508121
  • ENSP00000422175
  • ENST00000553379
  • ENSP00000452340
  • ENST00000554144
  • ENSP00000450527
  • ENST00000555760
  • ENSP00000452098
  • ENST00000556376
  • ENSP00000451794
  • ENST00000556614
  • ENSP00000452003

Symbol
  • HOD
  • HOP
  • LAGY
  • NECC1
  • OB1
  • HOD
  • HOP
  • OB1
  • LAGY
  • TOTO
  • CAMEO
  • NECC1
  • SMAP31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
PubMedID
0.9
gene perturbation
0.86
biological process
0.85
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.07   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.07   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0