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Tbio
HOPX
Homeodomain-only protein

Protein Summary
Description
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317745
  • ENSP00000315198
  • ENSG00000171476
  • ENST00000337881
  • ENSP00000337330
  • ENST00000381255
  • ENSP00000370654
  • ENST00000381260
  • ENSP00000370659
  • ENST00000420433
  • ENSP00000396275
  • ENST00000503639
  • ENSP00000424101
  • ENST00000508121
  • ENSP00000422175
  • ENST00000553379
  • ENSP00000452340
  • ENST00000554144
  • ENSP00000450527
  • ENST00000555760
  • ENSP00000452098
  • ENST00000556376
  • ENSP00000451794
  • ENST00000556614
  • ENSP00000452003

Symbol
  • HOD
  • HOP
  • LAGY
  • NECC1
  • OB1
  • HOD
  • HOP
  • OB1
  • LAGY
  • TOTO
  • CAMEO
  • NECC1
  • SMAP31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
PubMedID
0.9
gene perturbation
0.86
biological process
0.85
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.83   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.83   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
53.4
reticulocyte measurement
2
1
2
27.7
reticulocyte count
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
53.4
reticulocyte measurement
2
27.7
reticulocyte count
1
18.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HOP homeobox
694219
Mouse
MGI:1916782
74318
Rat
RGD:621841
171160
Dog
HOP homeobox
VGNC:41743
100855799
Cow
HOP homeobox
VGNC:29907
281270
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HOP homeobox
Mouse
Rat
Dog
HOP homeobox
Cow
HOP homeobox
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BPY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (37)
1 – 10 of 37
INTS13
Tbio
Novelty: 0.05454723
p_int: 0.993723063
p_ni: 0.001438061
p_wrong: 0.004838876
Score: 0.692
Data Source: BioPlex,STRINGDB
SRF
Tbio
Family: TF
Novelty: 0.00088839
Score: 0.975
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.768
Data Source: STRINGDB
SRI
Tbio
Novelty: 0.00237519
Score: 0.747
Data Source: STRINGDB
LRIG1
Tbio
Novelty: 0.01078663
Score: 0.674
Data Source: STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.659
Data Source: STRINGDB
NKX2-1
Tbio
Family: TF
Novelty: 0.00077491
Score: 0.656
Data Source: STRINGDB
PTPRZ1
Tbio
Family: Enzyme
Novelty: 0.00518159
Score: 0.633
Data Source: STRINGDB
ABCB4
Tbio
Family: Transporter
Novelty: 0.00080254
Score: 0.629
Data Source: STRINGDB
ASCL2
Tbio
Family: TF
Novelty: 0.0090207
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  249.83

PubMed score by year
PubTator Score  219.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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