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Tbio
MICU1
Calcium uptake protein 1, mitochondrial

Protein Summary
Description
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361114
  • ENSP00000354415
  • ENSG00000107745
  • ENST00000398763
  • ENSP00000381747
  • ENST00000418483
  • ENSP00000402470

Symbol
  • CALC
  • CBARA1
  • CALC
  • EFHA3
  • MPXPS
  • CBARA1
  • ara CALC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
transcription factor binding site profile
0.82
cellular component
0.78
cell type or tissue
0.71
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.28   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.28   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
56.9
C-reactive protein measurement
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
56.9
C-reactive protein measurement
1
10.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake 1
VGNC:4783
736009
Mouse
MGI:2384909
216001
Rat
RGD:735033
365567
Dog
mitochondrial calcium uptake 1
VGNC:43220
479241
Horse
mitochondrial calcium uptake 1
VGNC:20172
100063651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake 1
Mouse
Rat
Dog
mitochondrial calcium uptake 1
Horse
mitochondrial calcium uptake 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BPX6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Protein-Protein Interactions (81)
1 – 10 of 81
MICU2
Tbio
Novelty: 0.04146208
p_int: 0.999999997
p_ni: 3e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
MICU3
Tbio
Novelty: 0.09752188
p_int: 0.998753401
p_ni: 1.65e-7
p_wrong: 0.001246434
Score: 0.986
Data Source: BioPlex,STRINGDB
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.998415165
p_ni: 0.001584835
Data Source: BioPlex
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.99680192
p_ni: 0.00319808
Data Source: BioPlex
DCAF8L2
Tdark
Novelty: 6.73057868
p_int: 0.985537972
p_ni: 0.014462028
Data Source: BioPlex
CD79A
Tbio
Novelty: 0.00118942
p_int: 0.964775136
p_ni: 0.035224863
p_wrong: 1e-9
Data Source: BioPlex
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.962832668
p_ni: 0.037167332
Score: 0.671
Data Source: BioPlex,STRINGDB
GPN3
Tbio
Family: Enzyme
Novelty: 0.13817794
p_int: 0.949148966
p_ni: 0.050851023
p_wrong: 1.1e-8
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.943384613
p_ni: 0.056615386
p_wrong: 1e-9
Data Source: BioPlex
THUMPD3
Tdark
Novelty: 0.23224828
p_int: 0.93473811
p_ni: 0.065261889
Data Source: BioPlex
Publication Statistics
PubMed Score  111.28

PubMed score by year
PubTator Score  108.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer