You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ARPC5L
Actin-related protein 2/3 complex subunit 5-like protein

Protein Summary
Description
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259477
  • ENSP00000259477
  • ENSG00000136950
  • ENST00000353214
  • ENSP00000345361

Symbol
  • ARC16-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
disease perturbation
0.83
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
7.1
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
7.1
71.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 5 like
VGNC:13853
739553
Mouse
MGI:1921442
74192
Rat
RGD:1308867
296710
Dog
actin related protein 2/3 complex subunit 5 like
VGNC:38132
612856
Horse
actin related protein 2/3 complex subunit 5 like
VGNC:15540
100067289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 5 like
Mouse
Rat
Dog
actin related protein 2/3 complex subunit 5 like
Horse
actin related protein 2/3 complex subunit 5 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BPX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Fc gamma R-mediated phagocytosis
KEGG
Salmonella infection
KEGG
Endocytosis
KEGG
Regulation of actin cytoskeleton
KEGG
Bacterial invasion of epithelial cells
Name
Explore in Pharos
Explore in Source
Fc gamma R-mediated phagocytosis
Salmonella infection
Endocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (55)
1 – 10 of 55
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.995238855
p_ni:  0.004761145
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARPC1B
Tbio
Novelty:  0.03873325
p_int:  0.973812492
p_ni:  0.026187508
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.920002536
p_ni:  0.079997464
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.896581186
p_ni:  0.103418814
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
Score:  0.999
Data Source:  STRINGDB
ARPC1A
Tbio
Novelty:  0.07577807
Score:  0.999
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.999
Data Source:  STRINGDB
ARPC4
Tbio
Novelty:  0.04212335
Score:  0.999
Data Source:  STRINGDB
ACTR3C
Tdark
Novelty:  0.16443513
Score:  0.861
Data Source:  STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
Score:  0.841
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.02

PubMed score by year
PubTator Score  2.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer