Tdark ARPC5L Actin-related protein 2/3 complex subunit 5-like protein

Protein Summary

Description

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Uniprot Accession IDs

• Q9BPX5
• Q7Z523

Gene Name

• ARPC5L

Ensembl ID

• ENST00000259477
• ENSP00000259477
• ENSG00000136950
• ENST00000353214
• ENSP00000345361

Symbol

• ARC16-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
disease perturbation	0.83
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 5-like Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 5-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.99   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.99   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0