HSD17B14
17-beta-hydroxysteroid dehydrogenase 14
Protein Summary
Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
- ENST00000263278
- ENSP00000263278
- ENSG00000087076
- DHRS10
- SDR3
- SDR47C1
- DHRS10
- SDR47C1
- retSDR3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.77 | ||
transcription factor perturbation | 0.61 | ||
protein domain | 0.58 | ||
transcription factor binding site profile | 0.57 | ||
cell type or tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.46 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.46 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 45
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0