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Tchem
HSD17B14
17-beta-hydroxysteroid dehydrogenase 14

Protein Summary
Description
Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263278
  • ENSP00000263278
  • ENSG00000087076

Symbol
  • DHRS10
  • SDR3
  • SDR47C1
  • DHRS10
  • SDR47C1
  • retSDR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor perturbation
0.61
protein domain
0.58
transcription factor binding site profile
0.57
cell type or tissue
0.52


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 14
VGNC:13324
747021
Mouse
MGI:1913315
66065
Rat
RGD:1588673
691018
Dog
hydroxysteroid 17-beta dehydrogenase 14
VGNC:41804
476420
Horse
hydroxysteroid 17-beta dehydrogenase 14
VGNC:18886
100051311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 14
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 14
Horse
hydroxysteroid 17-beta dehydrogenase 14
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BPX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Estrogen biosynthesis (R-HSA-193144)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Estrogen biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Estrogen biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Protein-Protein Interactions (26)
1 – 10 of 26
CHKB
Tbio
Family: Kinase
Novelty: 0.00862294
Score: 0.618
Data Source: STRINGDB
MIOX
Tbio
Family: Enzyme
Novelty: 0.00962281
Score: 0.609
Data Source: STRINGDB
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
Score: 0.601
Data Source: STRINGDB
DHDH
Tbio
Family: Enzyme
Novelty: 0.00284827
Score: 0.598
Data Source: STRINGDB
BCAT2
Tchem
Family: Enzyme
Novelty: 0.00885158
Score: 0.555
Data Source: STRINGDB
RCBTB1
Tbio
Novelty: 0.12259073
Score: 0.55
Data Source: STRINGDB
BCAT1
Tchem
Family: Enzyme
Novelty: 0.00616446
Score: 0.54
Data Source: STRINGDB
BRIP1
Tbio
Novelty: 0.03886334
Score: 0.539
Data Source: STRINGDB
CAVIN2
Tbio
Novelty: 0.00979388
Score: 0.53
Data Source: STRINGDB
CC2D1B
Tbio
Novelty: 0.22031767
Score: 0.521
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.03

PubMed score by year
PubTator Score  3.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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