You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
B9D2
B9 domain-containing protein 2

Protein Summary
Description
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243578
  • ENSP00000243578
  • ENSG00000123810

Symbol
  • MKSR2
  • MKS10
  • MKSR2
  • ICIS-1
  • JBTS34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
small molecule perturbation
0.62
tissue sample
0.59
cell line
0.58
cellular component
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
B9D1
Tbio
Novelty:  0.11567839
p_int:  0.999999887
p_ni:  1.12e-7
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
p_int:  0.999998332
p_ni:  0.000001668
Data Source:  BioPlex
CC2D2A
Tbio
Novelty:  0.03684487
p_int:  0.999995781
p_ni:  0.000003517
p_wrong:  7.02e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
MKS1
Tbio
Novelty:  0.02463305
p_int:  0.999903667
p_ni:  0.000096333
Score:  0.948
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.994048748
p_ni:  0.005951251
Data Source:  BioPlex
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.98819066
p_ni:  0.000244957
p_wrong:  0.011564384
Score:  0.989
Data Source:  BioPlex,STRINGDB
TCTN1
Tbio
Novelty:  0.0657704
p_int:  0.948150263
p_ni:  0.051802561
p_wrong:  0.000047176
Score:  0.995
Data Source:  BioPlex,STRINGDB
TMEM216
Tbio
Novelty:  0.07870718
Score:  0.985
Data Source:  STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.985
Data Source:  STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
9
6
1.1
98.4
balding measurement
2
3
3
95.7
body height
3
3
3
93.9
serum gamma-glutamyl transferase measurement
3
2
3
91.7
type 2 diabetes mellitus
1
1
0
1.4
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.1
98.4
balding measurement
3
95.7
body height
3
93.9
serum gamma-glutamyl transferase measurement
3
91.7
type 2 diabetes mellitus
0
1.4
89.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
B9 domain containing 2
704873
Mouse
MGI:2387643
232987
Rat
RGD:1566122
308443
Horse
B9 domain containing 2
VGNC:15748
100146820
Cow
B9 domain containing 2
VGNC:26397
616609
Species
Name
OMA
EggNOG
Inparanoid
Macaque
B9 domain containing 2
Mouse
Rat
Horse
B9 domain containing 2
Cow
B9 domain containing 2
Publication Statistics
PubMed Score 9.81
PubMed score by year
PubTator Score 3.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title