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Tbio
GAL3ST1
Galactosylceramide sulfotransferase

Protein Summary
Description
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338911
  • ENSP00000343234
  • ENSG00000128242
  • ENST00000401975
  • ENSP00000384388
  • ENST00000402321
  • ENSP00000385735
  • ENST00000402369
  • ENSP00000384122
  • ENST00000406361
  • ENSP00000385207
  • ENST00000406955
  • ENSP00000385825

Symbol
  • CST
  • CST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.83
tissue
0.66
cell type or tissue
0.63
cellular component
0.63
phenotype
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.999999215
p_ni:  7.84e-7
p_wrong:  1e-9
Score:  0.382
Data Source:  BioPlex,STRINGDB
PSG4
Tbio
Novelty:  0.09464871
p_int:  0.994907107
p_ni:  0.005058992
p_wrong:  0.000033901
Score:  0.534
Data Source:  BioPlex,STRINGDB
PIGW
Tbio
Novelty:  0.0245774
p_int:  0.978504242
p_ni:  0.012429274
p_wrong:  0.009066483
Score:  0.243
Data Source:  BioPlex,STRINGDB
NDUFA3
Tclin
Family:  Enzyme
Novelty:  0.21111937
p_int:  0.969279406
p_ni:  0.030720433
p_wrong:  1.61e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
LRIG3
Tbio
Novelty:  0.04502029
p_int:  0.950202922
p_ni:  0.049797078
Score:  0.907
Data Source:  BioPlex,STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.912886974
p_ni:  0.087113026
Score:  0.725
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.895452915
p_ni:  0.104547085
Data Source:  BioPlex
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
Score:  0.955
Data Source:  STRINGDB
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
Score:  0.953
Data Source:  STRINGDB
NEU2
Tbio
Family:  Enzyme
Novelty:  0.00460828
Score:  0.945
Data Source:  STRINGDB
Pathways (11)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ether lipid metabolism
KEGG
Metabolic pathways
KEGG
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Ether lipid metabolism
Metabolic pathways
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
93.1
mean corpuscular volume
1
2
2
61.8
reticulocyte measurement
2
2
3
61.8
high density lipoprotein cholesterol measurement
1
1
1
61.4
apolipoprotein A 1 measurement
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
93.1
mean corpuscular volume
2
61.8
reticulocyte measurement
3
61.8
high density lipoprotein cholesterol measurement
1
61.4
apolipoprotein A 1 measurement
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galactose-3-O-sulfotransferase 1
VGNC:5263
458758
Mouse
MGI:1858277
53897
Rat
RGD:1583379
683713
Dog
galactose-3-O-sulfotransferase 1
VGNC:41076
611960
Horse
galactose-3-O-sulfotransferase 1
VGNC:18213
100063781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galactose-3-O-sulfotransferase 1
Mouse
Rat
Dog
galactose-3-O-sulfotransferase 1
Horse
galactose-3-O-sulfotransferase 1
Publication Statistics
PubMed Score 32.78
PubMed score by year
PubTator Score 18.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title