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Tbio
AKAP9
A-kinase anchor protein 9

Protein Summary
Description
Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). Isoform 4: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as wel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356239
  • ENSP00000348573
  • ENSG00000127914

Symbol
  • AKAP350
  • AKAP450
  • KIAA0803
  • LQT11
  • PRKA9
  • AKAP-9
  • CG-NAP
  • YOTIAO
  • AKAP350
  • AKAP450
  • PPP1R45
  • HYPERION
  • MU-RMS-40.16A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
biological process
0.85
cellular component
0.83
transcription factor binding site profile
0.76
interacting protein
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.89   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.89   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 9
VGNC:4254
472440
Macaque
A-kinase anchoring protein 9
702970
Mouse
MGI:2178217
100986
Rat
RGD:620833
246150
Dog
A-kinase anchoring protein 9
VGNC:37763
475224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 9
Macaque
A-kinase anchoring protein 9
Mouse
Rat
Dog
A-kinase anchoring protein 9
Pathways (91)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cardiac conduction
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cardiac conduction
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (314)
1 – 10 of 314
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.999998956
p_ni: 0.000001044
Score: 0.979
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.999998835
p_ni: 0.000001165
Score: 0.954
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999985171
p_ni: 0.000014828
Score: 0.923
Data Source: BioPlex,STRINGDB
SSX2
Tbio
Novelty: 0.00227167
p_int: 0.999193422
p_ni: 0.000806577
p_wrong: 1e-9
Score: 0.547
Data Source: BioPlex,STRINGDB
CSNK1D
Tchem
Family: Kinase
Novelty: 0.00896935
p_int: 0.999149517
p_ni: 0.000850475
p_wrong: 8e-9
Score: 0.955
Data Source: BioPlex,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
p_int: 0.998867271
p_ni: 0.001132729
Score: 0.973
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.997997125
p_ni: 0.002002875
Data Source: BioPlex
C1orf87
Tbio
Novelty: 0.03162594
p_int: 0.997820674
p_ni: 0.002179326
Score: 0.512
Data Source: BioPlex,STRINGDB
CEP170
Tbio
Novelty: 0.05342931
p_int: 0.995634686
p_ni: 0.004365314
Score: 0.636
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.990879977
p_ni: 0.009120023
Score: 0.46
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  96.89

PubMed score by year
PubTator Score  63.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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