You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GDF15
Growth/differentiation factor 15

Protein Summary
Description
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252809
  • ENSP00000252809
  • ENSG00000130513

Symbol
  • MIC1
  • PDF
  • PLAB
  • PTGFB
  • PDF
  • MIC1
  • PLAB
  • MIC-1
  • NAG-1
  • PTGFB
  • GDF-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
gene perturbation
0.99
biological term
0.98
virus perturbation
0.94
transcription factor binding site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.23   (req: < 5)
Gene RIFs: 306   (req: <= 3)
Antibodies: 898   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.23   (req: >= 5)
Gene RIFs: 306   (req: > 3)
Antibodies: 898   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
3
5
5
99.8
nausea and vomiting of pregnancy severity measurement
1
1
1
43
hyperemesis gravidarum
1
1
0
1.5
42.1
coffee consumption measurement
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
5
99.8
nausea and vomiting of pregnancy severity measurement
1
43
hyperemesis gravidarum
0
1.5
42.1
coffee consumption measurement
1
11.3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
Cytokine-cytokine receptor interaction
Protein-Protein Interactions (94)
1 – 10 of 94
GFRAL
Tbio
Novelty: 0.04350123
Score: 0.929
Data Source: STRINGDB
HAMP
Tbio
Novelty: 0.00035828
Score: 0.832
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.789
Data Source: STRINGDB
ATF3
Tbio
Family: TF
Novelty: 0.00164508
Score: 0.746
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.719
Data Source: STRINGDB
DDIT3
Tchem
Family: TF
Novelty: 0.00116135
Score: 0.708
Data Source: STRINGDB
DDIT3
Tbio
Novelty: 0.00116135
Score: 0.708
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.703
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.665
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.659
Data Source: STRINGDB
Publication Statistics
PubMed Score  1275.23

PubMed score by year
PubTator Score  692.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: