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Tbio
VRK1
Serine/threonine-protein kinase VRK1

Protein Summary
Description
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216639
  • ENSP00000216639
  • ENSG00000100749

Symbol
  • PCH1
  • PCH1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.97
kinase perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.43   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.43   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Reactome
Mitotic Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Initiation of Nuclear Envelope Reformation
M Phase
Mitotic Anaphase
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (147)
1 – 10 of 147
ZBTB42
Tbio
Family: TF
Novelty: 0.47619048
p_int: 0.999993392
p_ni: 0.000006608
Score: 0.232
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.16730745
p_int: 0.99486843
p_ni: 0.005131569
p_wrong: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.00944493
p_int: 0.993799804
p_ni: 0.006200194
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00757235
p_int: 0.99278544
p_ni: 0.00721456
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.00028982
p_int: 0.991814567
p_ni: 0.008185176
p_wrong: 2.58e-7
Score: 0.156
Data Source: BioPlex,STRINGDB
USP47
Tchem
Family: Enzyme
Novelty: 0.12618297
p_int: 0.990478372
p_ni: 0.009521628
Score: 0.156
Data Source: BioPlex,STRINGDB
SERPINB5
Tbio
Novelty: 0.00088182
p_int: 0.98771255
p_ni: 0.01228735
p_wrong: 1e-7
Score: 0.169
Data Source: BioPlex,STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00875526
p_int: 0.847319553
p_ni: 0.151186166
p_wrong: 0.00149428
Score: 0.183
Data Source: BioPlex,STRINGDB
RABIF
Tbio
Novelty: 0.63157895
p_int: 0.840469468
p_ni: 0.049834556
p_wrong: 0.109695976
Data Source: BioPlex
SLC38A7
Tdark
Family: Transporter
Novelty: 0.30036308
p_int: 0.810771078
p_ni: 0.188164173
p_wrong: 0.00106475
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  118.43

PubMed score by year
PubTator Score  71.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer