Tbio OMD Osteomodulin

Protein Summary

Description

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).

Uniprot Accession IDs

• Q99983
• Q5TBF4

Gene Name

• OMD

Ensembl ID

• ENST00000375550
• ENSP00000364700
• ENSG00000127083

Symbol

• SLRR2C
• OSAD
• SLRR2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.93
gene perturbation	0.68
kinase perturbation	0.66
disease	0.58
cellular component	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.43   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.43   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

APAF1

Tchem

Family:  Enzyme

Novelty:  0.00107622

p_int:  0.999852449

p_ni:  0.000147534

p_wrong:  1.6e-8

Score:  0.24

Data Source:  BioPlex,STRINGDB

PATZ1

Tbio

Family:  TF

Novelty:  0.02038599

p_int:  0.973033422

p_ni:  0.026966569

p_wrong:  9e-9

Score:  0.209

Data Source:  BioPlex,STRINGDB

BBS1

Tbio

Novelty:  0.00939439

p_int:  0.911637683

p_ni:  0.088362317

Score:  0.187

Data Source:  BioPlex,STRINGDB

SUMF1

Tbio

Family:  Enzyme

Novelty:  0.00954537

p_int:  0.7761673

p_ni:  0.015658529

p_wrong:  0.208174171

Score:  0.237

Data Source:  BioPlex,STRINGDB

ACAN

Tbio

Novelty:  0.00033695

Score:  0.965

Data Source:  STRINGDB

OGN

Tbio

Novelty:  0.00097407

Score:  0.964

Data Source:  STRINGDB

FMOD

Tbio

Novelty:  0.00459438

Score:  0.917

Data Source:  STRINGDB

PRELP

Tbio

Novelty:  0.02849334

Score:  0.914

Data Source:  STRINGDB

LUM

Tbio

Novelty:  0.00219939

Score:  0.911

Data Source:  STRINGDB

KERA

Tbio

Novelty:  0.00789599

Score:  0.907

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (12)

Reactome (12)

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

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Find Similar Targets

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5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	8 targets	R-HSA-3656244
Reactome	Defective CHST6 causes MCDC1	8 targets	R-HSA-3656225
Reactome	Defective ST3GAL3 causes MCT12 and EIEE15	8 targets	R-HSA-3656243
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with glycosaminoglycan metabolism	41 targets	R-HSA-3560782

Name	Explore in Pharos	Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	8 targets	R-HSA-3656244
Defective CHST6 causes MCDC1	8 targets	R-HSA-3656225
Defective ST3GAL3 causes MCT12 and EIEE15	8 targets	R-HSA-3656243
Disease	1105 targets	R-HSA-1643685
Diseases associated with glycosaminoglycan metabolism	41 targets	R-HSA-3560782

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Components (5)

Processes (4)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
extracellular region	Traceable Author Statement (TAS)	Reactome
Golgi lumen	Traceable Author Statement (TAS)	Reactome
lysosomal lumen	Traceable Author Statement (TAS)	Reactome
collagen-containing extracellular matrix	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systolic blood pressure	EFO_0006335	1	1	1		58.9
blood protein measurement	EFO_0007937	1	1	1		55
triglyceride measurement	EFO_0004530	1	1	1		33.8
body mass index	EFO_0004340	1	1	1		27.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systolic blood pressure	EFO_0006335	1		58.9
blood protein measurement	EFO_0007937	1		55
triglyceride measurement	EFO_0004530	1		33.8
body mass index	EFO_0004340	1		27.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell adhesion
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Polymorphism
Proteoglycan
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
body mass index
systolic blood pressure
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	osteomodulin	VGNC:8917	739996
Mouse	osteomodulin	MGI:1350918	27047
Rat	osteomodulin	RGD:621818	83717
Dog	osteomodulin	VGNC:44122	102154566
Horse	osteomodulin	VGNC:21032	102149475

Species	Name	OMA	EggNOG	Inparanoid
Chimp	osteomodulin
Mouse	osteomodulin
Rat	osteomodulin
Dog	osteomodulin
Horse	osteomodulin

Publication Statistics

PubMed Score 121.43

PubMed score by year

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PubTator Score 8.41

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (4)

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10

0 of 0

PMID	Year	Title