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Tbio
OMD
Osteomodulin

Protein Summary
Description
May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375550
  • ENSP00000364700
  • ENSG00000127083

Symbol
  • SLRR2C
  • OSAD
  • SLRR2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
gene perturbation
0.68
kinase perturbation
0.66
disease
0.58
cellular component
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
56
triglyceride measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
56
triglyceride measurement
1
44.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
osteomodulin
VGNC:8917
739996
Mouse
MGI:1350918
27047
Rat
RGD:621818
83717
Dog
osteomodulin
VGNC:44122
102154566
Horse
osteomodulin
VGNC:21032
102149475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
osteomodulin
Mouse
Rat
Dog
osteomodulin
Horse
osteomodulin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99983-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (54)
1 – 10 of 54
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.999852449
p_ni:  0.000147534
p_wrong:  1.6e-8
Score:  0.24
Data Source:  BioPlex,STRINGDB
PATZ1
Tbio
Family:  TF
Novelty:  0.02038599
p_int:  0.973033422
p_ni:  0.026966569
p_wrong:  9e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
BBS1
Tbio
Novelty:  0.00939439
p_int:  0.911637683
p_ni:  0.088362317
Score:  0.187
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.7761673
p_ni:  0.015658529
p_wrong:  0.208174171
Score:  0.237
Data Source:  BioPlex,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.965
Data Source:  STRINGDB
OGN
Tbio
Novelty:  0.00097407
Score:  0.964
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.917
Data Source:  STRINGDB
PRELP
Tbio
Novelty:  0.02849334
Score:  0.914
Data Source:  STRINGDB
LUM
Tbio
Novelty:  0.00219939
Score:  0.911
Data Source:  STRINGDB
KERA
Tbio
Novelty:  0.00789599
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  54.37

PubMed score by year
PubTator Score  8.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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